Gene: RASSF6
Official Full Name: Ras association domain family member 6provided by HGNC
Gene Summary: This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08597 | RASSF6 Knockout cell line (HCT 116) | Human | RASSF6 | 1:2~1:4 | Negative | Online Inquiry |
KO08598 | RASSF6 Knockout cell line (A549) | Human | RASSF6 | 1:3~1:4 | Negative | Online Inquiry |
RASSF6 Gene Knockout Cell Lines are genetically modified cell lines characterized by the ablation of the RASSF6 gene, which encodes a member of the Ras association domain family. This gene plays a critical role in regulating cell proliferation, apoptosis, and tumor growth, thereby serving as a vital component of cellular signaling pathways involved in cancer biology. Utilizing CRISPR-Cas9 technology or other gene-editing methods, these knockout cell lines enable researchers to investigate the functional impact of RASSF6 absence on cellular behavior and signaling cascades.
The primary function of RASSF6 involves the modulation of Ras signaling pathways, offering insights into cell cycle regulation and tumorigenesis. By studying these knockout lines, researchers can elucidate the downstream effects of RASSF6 loss, such as altered apoptotic responses and aberrant cell division, which are critical for understanding cancer pathophysiology. This product is particularly important for cancer research, as it provides a model to study tumor suppressor functions, drug resistance mechanisms, and the cellular responses to various therapeutic agents.
Compared to other genetic models, RASSF6 Gene Knockout Cell Lines offer distinct advantages, including the ability to study the specific contributions of RASSF6 in a controlled cellular environment and the versatility for applications in high-throughput screening and drug development. Moreover, these cell lines pave the way for studying complex interactions within the Ras signaling network, which is often dysregulated in various cancers.
For researchers and clinicians, the availability of RASSF6 Gene Knockout Cell Lines represents a valuable tool to advance the understanding of cancer biology and facilitate the development of targeted therapies. By providing clear insights into the role of tumor suppressor genes, this product empowers scientists to design experiments that could lead to breakthroughs in cancer treatment strategies.
Our company is committed to advancing biological research through the development of high-quality genetic models, such as the RASSF6 Gene Knockout Cell Lines, that can meet the diverse needs of the research community. With our robust expertise in genetic engineering and a focus on innovation, we strive to deliver products that enhance scientific discovery and improve health outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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