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RASGRP1 Knockout Cell Lines

Gene: RASGRP1

Official Full Name: RAS guanyl releasing protein 1provided by HGNC

Gene Summary: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00666 RASGRP1 Knockout cell line(HEK293) Human RASGRP1 1:3~1:6 Negative Online Inquiry
KO10512 RASGRP1 Knockout cell line (HeLa) Human RASGRP1 1:3~1:6 Negative Online Inquiry
KO10513 RASGRP1 Knockout cell line (A549) Human RASGRP1 1:3~1:4 Negative Online Inquiry

Background

RASGRP1 Gene Knockout Cell Lines are a specialized biological tool designed for the comprehensive study of the RASGRP1 gene, a critical regulator in cellular signaling processes. These cell lines are created using advanced gene editing technologies, such as CRISPR/Cas9, to precisely knockout the RASGRP1 gene, enabling researchers to investigate its role in various physiological and pathological contexts.

The primary function of RASGRP1 is to activate RAS proteins, which are pivotal in mediating signaling pathways that regulate cell growth, differentiation, and granule secretion, particularly in immune cells. By employing RASGRP1 knockout cell lines, researchers can elucidate the mechanistic pathways involved in RAS signaling, assess the consequences of RASGRP1 depletion on cell function, and explore its implications in diseases such as autoimmunity, cancer, and immune deficiencies.

The scientific importance of RASGRP1 Gene Knockout Cell Lines lies in their applicability to both basic research and clinical studies. In research settings, these cell lines enable detailed analysis of gene function, aiding in the identification of potential therapeutic targets. In clinical contexts, they can serve as valuable models for drug screening and development, particularly for therapies aimed at modulating RAS signaling.

Compared to conventional cell lines or studies employing RNA interference, RASGRP1 knockout cell lines offer a more stable and complete gene disruption, leading to clearer phenotypic outcomes and insights into the gene's biological roles. They also provide a more consistent and reproducible platform for experimentation, which is pivotal for validating research findings.

For researchers and clinicians invested in the field of molecular biology and therapeutic development, RASGRP1 Gene Knockout Cell Lines present a unique opportunity to deepen understanding and facilitate discovery in RAS signaling mechanisms. This product exemplifies our commitment to advancing scientific research through innovative and precise tools. Our company specializes in the production of high-quality biological products, ensuring that every researcher has access to reliable and cutting-edge resources for their work.

Please note that all services are for research use only. Not intended for any clinical use.

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