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RASAL2 Knockout Cell Lines

Gene: RASAL2

Official Full Name: RAS protein activator like 2provided by HGNC

Gene Summary: This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08972 RASAL2 Knockout cell line (HeLa) Human RASAL2 1:3~1:6 Negative Online Inquiry
KO08973 RASAL2 Knockout cell line (HCT 116) Human RASAL2 1:2~1:4 Negative Online Inquiry
KO08974 RASAL2 Knockout cell line (HEK293) Human RASAL2 1:3~1:6 Negative Online Inquiry
KO08975 RASAL2 Knockout cell line (A549) Human RASAL2 1:3~1:4 Negative Online Inquiry

Background

RASAL2 Gene Knockout Cell Lines are experimental models generated through advanced gene editing techniques to specifically disrupt the RASAL2 gene, which plays a significant role in various cellular processes, including RAS signaling pathway regulation. By creating these knockout cell lines, researchers can investigate the functional implications of RASAL2 loss on cellular proliferation, differentiation, and apoptosis, ultimately enhancing our understanding of its role in cancer metastasis and other diseases influenced by RAS signaling.

The mechanism of action of RASAL2 relates to its function as a RAS GTPase-activating protein (GAP), promoting the hydrolysis of RAS-bound GTP to GDP, thereby inactivating RAS signaling pathways. By knocking out RASAL2, cellular RAS activity can be increased, allowing researchers to explore downstream effects on various signal transduction pathways, which may lead to the discovery of novel therapeutic targets or biomarkers for malignancies.

The scientific importance of RASAL2 Gene Knockout Cell Lines lies in their potential applications in both research and clinical settings. They serve as valuable tools for understanding the intricate mechanisms of RAS-related cancers, as well as evaluating novel drug candidates targeting aberrant RAS signaling. By utilizing these cell lines, researchers can delineate the contribution of RASAL2 in tumorigenesis, enhancing the development of personalized medicine approaches in oncology.

What sets our RASAL2 Gene Knockout Cell Lines apart from other gene knockout models is the precision of our gene-editing technology, which ensures high efficiency and specificity in the disruption of the RASAL2 gene. Additionally, our extensive validation process guarantees that these cell lines maintain stable genetic characteristics and relevant phenotypic behaviors, which are crucial for reproducible experimental outcomes.

For researchers and clinicians aiming to elucidate the complexities of RAS signaling in disease, RASAL2 Gene Knockout Cell Lines offer an invaluable resource. We are committed to empowering scientific discovery with our high-quality biological products, backed by years of expertise in gene editing and cell line development. Our dedication ensures that you receive reliable, cutting-edge tools that can significantly advance your research and therapeutic endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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