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RAPGEFL1 Knockout Cell Lines

Gene: RAPGEFL1

Official Full Name: Rap guanine nucleotide exchange factor like 1provided by HGNC

Gene Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22886 RAPGEFL1 Knockout cell line (HeLa) Human RAPGEFL1 1:3~1:6 Negative Online Inquiry
KO22887 RAPGEFL1 Knockout cell line (HCT 116) Human RAPGEFL1 1:2~1:4 Negative Online Inquiry
KO22888 RAPGEFL1 Knockout cell line (HEK293) Human RAPGEFL1 1:3~1:6 Negative Online Inquiry
KO22889 RAPGEFL1 Knockout cell line (A549) Human RAPGEFL1 1:3~1:4 Negative Online Inquiry

Background

RAPGEFL1 Gene Knockout Cell Lines are genetically modified cellular models that have been engineered to express a complete knockout of the RAPGEFL1 gene. This gene encodes a protein that regulates various intracellular signaling pathways, particularly those involved in cell growth and differentiation. By creating cell lines devoid of RAPGEFL1, researchers gain vital insights into the gene's role in cellular processes, disease mechanisms, and potential therapeutic interventions.

The primary function of these knockout cell lines lies in their ability to elucidate the biological effects associated with the absence of RAPGEFL1. Utilizing CRISPR-Cas9 technology, the RAPGEFL1 gene has been precisely targeted to disrupt its expression, permitting a comprehensive analysis of downstream effects on signaling cascades. This approach enables researchers to study alterations in pathways related to cancer, neurological disorders, or metabolic diseases, thereby facilitating hypothesis generation and validation in preclinical studies.

The scientific importance of RAPGEFL1 Gene Knockout Cell Lines is significant in both research and clinical settings. They serve as invaluable tools for understanding gene function and its implications in health and disease. Furthermore, these cell lines are crucial for drug discovery efforts, where understanding the specific pathways involved in drug response or resistance can lead to more effective therapeutic strategies.

What sets RAPGEFL1 Gene Knockout Cell Lines apart from alternatives is their specificity and reliability. Unlike traditional knockout methods, the CRISPR-Cas9-based approach provides a high degree of precision with minimal off-target effects, ensuring that the observed phenotypes are directly attributable to the RAPGEFL1 gene disruption. This specificity leads to reproducible results, which are vital for publishing high-impact findings.

For researchers and clinicians focused on advancing our understanding of genetic regulation and disease mechanisms, RAPGEFL1 Gene Knockout Cell Lines present a robust platform for innovative research. The potential to dissect complex biological questions and translate findings into clinical applications enhances their value significantly.

Our company specializes in the development and distribution of cutting-edge biological tools, ensuring researchers have access to high-quality, reliable resources that support their scientific endeavors. With our commitment to innovation, we are dedicated to empowering the research community with products that pave the way for groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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