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RALGAPA1 Knockout Cell Lines

Gene: RALGAPA1

Official Full Name: Ral GTPase activating protein catalytic subunit alpha 1provided by HGNC

Gene Summary: This gene encodes a major subunit of the RAL-GTPase activating protein. A similar protein in mouse binds E12, a transcriptional regulator of immunoglobulin genes. The mouse protein also functions in skeletal muscle by binding to the regulatory 14-3-3 proteins upon stimulation with insulin or muscle contraction. A pseudogene of this gene has been identified on chromosome 9. [provided by RefSeq, Oct 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08936 RALGAPA1 Knockout cell line (HeLa) Human RALGAPA1 1:3~1:6 Negative Online Inquiry
KO08937 RALGAPA1 Knockout cell line (HCT 116) Human RALGAPA1 1:2~1:4 Negative Online Inquiry
KO08938 RALGAPA1 Knockout cell line (HEK293) Human RALGAPA1 1:3~1:6 Negative Online Inquiry
KO08939 RALGAPA1 Knockout cell line (A549) Human RALGAPA1 1:3~1:4 Negative Online Inquiry

Background

RALGAPA1 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to investigate the function of the RALGAPA1 gene, which encodes a protein implicated in various cellular processes such as signal transduction, cell proliferation, and cytoskeletal organization. By employing CRISPR/Cas9 gene editing technology, these knockout cell lines effectively silence RALGAPA1 expression, allowing researchers to explore the physiological roles and downstream effects of its loss under controlled experimental conditions.

The key function of RALGAPA1 is to serve as a guanine nucleotide exchange factor (GEF) for Ral small GTPases, crucial for regulating cellular signaling pathways. Knockout of this gene can elucidate its involvement in critical biological phenomena, such as cancer progression or neurodevelopmental disorders, making these cell lines significant tools for basic and translational research. In clinical settings, understanding RALGAPA1's role could lead to innovative therapeutic targets for various diseases where Ral signaling is aberrantly activated.

This product boasts several advantages over alternative gene editing models. RALGAPA1 Gene Knockout Cell Lines provide robust and reproducible systems that mimic relevant biological contexts. Their readiness-to-use format minimizes the complexities associated with the generation of custom knockout models, thus accelerating research timelines and enhancing experimental efficiency. Furthermore, researchers benefit from validated performance metrics and extensive support documentation, ensuring seamless integration into existing workflows.

Given the escalating need for accurate in vitro models in biological research, the RALGAPA1 Gene Knockout Cell Lines represent a valuable asset for both researchers and clinicians seeking to unravel the complexities of RALGAPA1’s role in health and disease. By fostering deeper insights through these precision models, our company, with its extensive expertise in gene editing and cell line development, is committed to empowering scientific innovation and advancing the frontiers of biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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