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RAET1L Knockout Cell Lines

Gene: RAET1L

Official Full Name: retinoic acid early transcript 1Lprovided by HGNC

Gene Summary: RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are located within a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extracellular alpha-1 and alpha-2 domains, but they lack the membrane proximal Ig-like alpha-3 domain. Most RAET1 glycoproteins are anchored to the membrane via glycosylphosphatidylinositol (GPI) linkage (Radosavljevic et al., 2002 [PubMed 11827464]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21472 RAET1L Knockout cell line (HCT 116) Human RAET1L 1:2~1:4 Negative Online Inquiry

Background

RAET1L Gene Knockout Cell Lines are specialized cell lines engineered to lack the RAET1L gene, a critical component in the immune response and tumor immunology. These knockout models facilitate the study of immune checkpoint regulation and the role of RAET1L in modulating NK cell activity. By providing a system devoid of this gene, researchers can explore the downstream effects on cellular signaling pathways involved in immune evasion and tumor progression.

The primary function of these knockout cell lines is to serve as a versatile platform for experimental procedures aimed at elucidating the role of RAET1L in immune dynamics. Through gene knockout technology, including CRISPR-Cas9 strategies, these cell lines exhibit a clear absence of RAET1L expression, allowing scientists to investigate the consequent changes in immune cell interactions, cytokine production, and resistance mechanisms in various cancers.

The scientific importance of RAET1L Gene Knockout Cell Lines lies in their potential applications in immunotherapy research, where enhancement of anti-tumor immunity is a focus. By utilizing these models, researchers can assess the efficacy of checkpoint inhibitors and novel therapeutic strategies aimed at reversing immune tolerance, leading to improved treatment options for cancer patients.

One distinct advantage of our RAET1L Gene Knockout Cell Lines is their rigorously validated genetic background and consistent performance in experimental settings, ensuring reliable and reproducible results. Unlike alternative products that may lack proper validation or specificity, our cell lines are designed to minimize variables and maximize the clarity of experimental outcomes.

This product is particularly valuable for researchers and clinicians keen on advancing their understanding of immune regulation in disease contexts, offering insights that could lead to groundbreaking therapeutic advancements. By using RAET1L Gene Knockout Cell Lines, scientists can contribute meaningfully to the field of immunology and oncology, potentially impacting patient care and treatment strategies.

Our company prides itself on delivering high-quality, scientifically robust biological products with a commitment to innovation and customer satisfaction. As industry leaders, we provide researchers with the resources they need to push the frontiers of scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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