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RAB8B Knockout Cell Lines

Gene: RAB8B

Official Full Name: RAB8B, member RAS oncogene familyprovided by HGNC

Gene Summary: RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]).[supplied by OMIM, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22216 RAB8B Knockout cell line (HeLa) Human RAB8B 1:3~1:6 Negative Online Inquiry
KO22217 RAB8B Knockout cell line (HCT 116) Human RAB8B 1:2~1:4 Negative Online Inquiry
KO22218 RAB8B Knockout cell line (HEK293) Human RAB8B 1:3~1:6 Negative Online Inquiry
KO22219 RAB8B Knockout cell line (A549) Human RAB8B 1:3~1:4 Negative Online Inquiry

Background

RAB8B Gene Knockout Cell Lines are engineered cellular models designed to facilitate the in-depth study of the RAB8B gene, which plays a crucial role in cellular processes such as vesicular trafficking, cytokinesis, and cell signaling. Utilizing CRISPR-Cas9 technology, these cell lines exhibit a specific knockout of the RAB8B gene, providing a powerful tool for elucidating the biological functions and pathways associated with RAB8B in various physiological and pathological contexts.

The key mechanism behind the RAB8B Gene Knockout Cell Lines lies in their ability to mimic the loss of function often observed in diseases related to dysfunctional cellular transport mechanisms. By creating a controlled environment where the RAB8B protein is absent, researchers can explore the consequences of this deficiency on cellular homeostasis, intercellular communication, and overall cellular dynamics. This is particularly significant in cancer research and neurodegenerative diseases, where altered vesicle transport has been implicated in disease progression and pathology.

In a research context, these specialized cell lines open avenues for high-throughput screening and functional assays aimed at identifying therapeutic targets or validating drug efficacy. Clinicians and researchers benefit from the ability to observe the effects of gene modification in real-time, thereby enhancing our understanding of disease mechanisms. Compared to other methods such as RNA interference or transient transfection, the RAB8B Gene Knockout Cell Lines provide a more stable and reproducible model, crucial for long-term studies.

Moreover, the specific knockout nature of these cell lines means minimal off-target effects, allowing for clearer interpretation of results. By utilizing RAB8B Gene Knockout Cell Lines, researchers can achieve unparalleled insights into the functional role of RAB8B, positioning themselves at the forefront of cellular and molecular biology research.

With years of expertise in developing high-quality biological research tools, our company is committed to advancing scientific innovation through reliable, state-of-the-art products like the RAB8B Gene Knockout Cell Lines. Our technical support and customer service ensure that users maximize the potential of our products, fostering an environment of collaborative scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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