Gene: RAB4A
Official Full Name: RAB4A, member RAS oncogene familyprovided by HGNC
Gene Summary: This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35728 | RAB4A Knockout cell line (HeLa) | Human | RAB4A | 1:3~1:6 | Negative | Online Inquiry |
KO35729 | RAB4A Knockout cell line (HCT 116) | Human | RAB4A | 1:2~1:4 | Negative | Online Inquiry |
KO35730 | RAB4A Knockout cell line (HEK293) | Human | RAB4A | 1:3~1:6 | Negative | Online Inquiry |
KO35731 | RAB4A Knockout cell line (A549) | Human | RAB4A | 1:3~1:4 | Negative | Online Inquiry |
RAB4A Gene Knockout Cell Lines are specialized cell lines engineered to lack the RAB4A gene, a critical component involved in endosomal trafficking. These cell lines provide researchers with a valuable tool for studying vesicular transport processes and the intracellular dynamics of protein sorting. The RAB4A protein primarily functions as a small GTPase residing on endosomes, where it plays a pivotal role in the regulation of membrane trafficking to the plasma membrane and recycling pathways. By knocking out RAB4A, researchers can elucidate its contributions to cellular processes, including receptor recycling, signaling, and overall cellular homeostasis.
The scientific importance of RAB4A Gene Knockout Cell Lines extends to their broad applications in both research and clinical settings. They serve as valuable models for investigating the dysregulation of endosomal trafficking implicated in various diseases, including cancer and neurodegenerative disorders. Furthermore, these cell lines can assist in high-throughput screening for potential therapeutic agents targeting these specific pathways, thus accelerating drug discovery and development processes.
Compared to traditional methods of gene silencing that may yield variable results, our RAB4A Gene Knockout Cell Lines provide a stable and complete loss of function for RAB4A, ensuring consistency and reproducibility in experimental outcomes. The precise genetic modification allows for comprehensive evaluations of gene function without the confounding factors typically associated with transient knockdown approaches.
For researchers and clinicians focused on advancing their understanding of cell biology and associated pathologies, these knockout cell lines offer invaluable insights and experimental advantages. Their unique genetic profile enables targeted investigation into the cellular mechanisms underlying complex diseases, establishing a clear advantage in precision research.
As a leader in biotechnological solutions, our company is dedicated to providing high-quality, well-characterized biological products, ensuring that our customers have access to the most reliable tools for their scientific inquiries. With a commitment to excellence and innovation in research products, we empower scientists to push the boundaries of discovery and translate their findings into meaningful clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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