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RAB43 Knockout Cell Lines

Gene: RAB43

Official Full Name: RAB43, member RAS oncogene familyprovided by HGNC

Gene Summary: Enables GTPase activity. Involved in Golgi organization; phagosome maturation; and retrograde transport, plasma membrane to Golgi. Located in Golgi apparatus and phagocytic vesicle. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00532 RAB43 gRNA5-gRNA6 KO plasmid RAB43 $850
GP00533 RAB43 gRNA3-gRNA4 KO plasmid RAB43 $850
KO14737 RAB43 Knockout cell line (HeLa) Human RAB43 1:3~1:6 Negative Online Inquiry
KO14738 RAB43 Knockout cell line (HCT 116) Human RAB43 1:2~1:4 Negative Online Inquiry
KO14739 RAB43 Knockout cell line (HEK293) Human RAB43 1:3~1:6 Negative Online Inquiry
KO14740 RAB43 Knockout cell line (A549) Human RAB43 1:3~1:4 Negative Online Inquiry

Background

RAB43 Gene Knockout Cell Lines are specialized cellular models that have been engineered to lack the RAB43 gene, a member of the RAB GTPase family that plays a crucial role in intracellular vesicle trafficking and membrane dynamics. These cell lines serve as invaluable tools for researchers aiming to understand the biological functions of RAB43, its role in cellular processes such as autophagy, endocytosis, and exocytosis, and its implications in various diseases, including cancer and neurodegenerative disorders.

The primary mechanism underlying the function of RAB43 involves regulating membrane fusion events and vesicular transport pathways critical for cellular homeostasis. By studying RAB43 knockout cells, scientists can elucidate the signaling pathways and molecular interactions that are disrupted upon its absence. This can lead to a deeper understanding of disease mechanisms and potential therapeutic targets.

The scientific significance of RAB43 Gene Knockout Cell Lines lies in their application across diverse fields, from basic research to drug development. These cell lines can be employed in high-throughput screening assays, genetic studies, and modeling disease states, thus providing robust platforms for testing pharmacological interventions and gene therapy approaches.

Compared to other gene knockout models, RAB43-specific knockout cell lines offer a precision tool designed to explore specific pathways involved in vesicle trafficking, with a streamlined approach that saves time and resources. Furthermore, these models are validated for functionality and reproducibility, ensuring consistent performance in experiments.

For researchers and clinicians, the value of RAB43 Gene Knockout Cell Lines is multifaceted. They not only facilitate advanced studies in cellular biology but also contribute significantly to the understanding of pathological processes, making them essential resources for innovative research strategies.

Our commitment to advancing biological research is evident in our expertise in developing high-quality cell models. Backed by years of experience and rigorous scientific standards, we provide researchers with reliable tools that drive discovery and innovation in the field of molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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