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RAB23 Knockout Cell Lines

Gene: RAB23

Official Full Name: RAB23, member RAS oncogene familyprovided by HGNC

Gene Summary: This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22237 RAB23 Knockout cell line (HeLa) Human RAB23 1:3~1:6 Negative Online Inquiry
KO22238 RAB23 Knockout cell line (HCT 116) Human RAB23 1:2~1:4 Negative Online Inquiry
KO22239 RAB23 Knockout cell line (HEK293) Human RAB23 1:3~1:6 Negative Online Inquiry
KO22240 RAB23 Knockout cell line (A549) Human RAB23 1:3~1:4 Negative Online Inquiry

Background

RAB23 Gene Knockout Cell Lines are genetically modified cell lines in which the RAB23 gene, a member of the RAB family of small GTPases, has been rendered non-functional through targeted CRISPR/Cas9 gene-editing technology. These cell lines serve as critical tools for elucidating the biological roles of RAB23 in cellular processes such as vesicle trafficking, cell cycle regulation, and development, offering researchers a powerful means to study gene function in a controlled environment.

The RAB23 protein is known to play a pivotal role in intracellular signaling pathways, particularly in the context of Hedgehog signaling, which is crucial for embryonic development and tissue patterning. By knocking out the RAB23 gene, researchers can investigate the resulting phenotypic changes, thereby providing insights into its function and implications in health and disease, such as cancer and developmental disorders. The knockout cell lines can be utilized in various applications, including drug screening, pathway analysis, and functional genomics.

One of the key advantages of our RAB23 Gene Knockout Cell Lines is their specificity and precision, which surpasses traditional gene silencing techniques such as RNA interference that can lead to off-target effects. Furthermore, these cell lines are validated and ready for immediate use, significantly reducing setup time for experiments. Coupled with our rigorous quality control measures, researchers can trust that these cell lines will deliver reproducible and reliable results.

The value of RAB23 Gene Knockout Cell Lines extends to both researchers and clinicians, as they facilitate the exploration of novel therapeutic targets and the underlying mechanisms of disease. Our extensive background in molecular biology and commitment to advancing scientific research ensures that we produce high-quality products tailored to meet the evolving needs of the life sciences community. Through robust support and a deep understanding of gene function, we empower our customers to drive innovation in their fields.

Please note that all services are for research use only. Not intended for any clinical use.

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