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RAB20 Knockout Cell Lines

Gene: RAB20

Official Full Name: RAB20, member RAS oncogene familyprovided by HGNC

Gene Summary: Predicted to enable GTPase activity. Involved in phagosome acidification and phagosome-lysosome fusion. Located in Golgi apparatus and phagocytic vesicle. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14750 RAB20 Knockout cell line (HeLa) Human RAB20 1:3~1:6 Negative Online Inquiry
KO14751 RAB20 Knockout cell line (HCT 116) Human RAB20 1:2~1:4 Negative Online Inquiry
KO14752 RAB20 Knockout cell line (HEK293) Human RAB20 1:3~1:6 Negative Online Inquiry

Background

RAB20 Gene Knockout Cell Lines are specialized cellular models in which the RAB20 gene, known for its role in intracellular vesicle trafficking and endosomal recycling, has been selectively disrupted. This gene knockout facilitates the investigation of RAB20's specific contributions to cellular processes, including membrane transport, signal transduction, and the regulation of autophagy. By providing a reliable tool for researchers, these cell lines enable detailed mechanistic studies that can elucidate the biological pathways influenced by RAB20, thereby unlocking insights into various diseases where disrupted trafficking is implicated.

The functionality of RAB20 Gene Knockout Cell Lines lies in their capability to mimic endogenous cellular environments while allowing researchers to observe and measure the physiological and pathological effects of the absence of the RAB20 protein. This enables the exploration of RAB20's involvement in critical biological processes, such as receptor recycling and pathogen resistance, as well as its potential impact on cancer progression and neurodegenerative diseases.

The scientific significance of these cell lines extends to their utility in both academic research and clinical applications, where they can be used to test therapeutic strategies targeting RAB20-associated pathways. Their implementation can aid in drug discovery processes, providing a robust platform for screening novel compounds aimed at modulating RAB20 function.

Compared to alternative models, such as overexpression systems or wild-type cell lines, RAB20 Gene Knockout Cell Lines present a unique advantage by offering a thorough understanding of the gene's loss-of-function effects in a controlled environment. This specificity enables more accurate data interpretation and validation of results, essential for translational research.

Researchers and clinicians benefit significantly from these cell lines as they provide a clear window into the cellular dynamics that govern health and disease states. These tools enhance not only the depth of research outcomes but also advance the development of targeted therapies.

As a leader in the field of biological products, our company is committed to providing high-quality, cutting-edge research tools. Our RAB20 Gene Knockout Cell Lines exemplify our expertise and dedication to supporting advancements in biological research and therapeutic innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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