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RAB1B Knockout Cell Lines

Gene: RAB1B

Official Full Name: RAB1B, member RAS oncogene familyprovided by HGNC

Gene Summary: Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25621 RAB1B Knockout cell line (HeLa) Human RAB1B 1:3~1:6 Negative Online Inquiry
KO25622 RAB1B Knockout cell line (HCT 116) Human RAB1B 1:2~1:4 Negative Online Inquiry
KO25623 RAB1B Knockout cell line (HEK293) Human RAB1B 1:3~1:6 Negative Online Inquiry
KO25624 RAB1B Knockout cell line (A549) Human RAB1B 1:3~1:4 Negative Online Inquiry

Background

RAB1B Gene Knockout Cell Lines are engineered cellular models designed to facilitate in-depth studies regarding the function of the RAB1B gene, which is pivotal in endoplasmic reticulum (ER) to Golgi transport processes. These cell lines feature a targeted deletion of the RAB1B gene, enabling researchers to observe the resultant phenotypic changes and cellular behaviors that occur when this specific gene is absent.

The primary function of RAB1B pertains to the regulation of vesicle trafficking, playing a crucial role in ensuring efficient protein sorting and delivery within cells. By utilizing these knockout cell lines, researchers can elucidate the mechanisms of intracellular transport, vesicle formation, and the involvement of RAB1B in various cellular pathways. This can offer insights into numerous physiological processes, including secretion, metabolism, and organelle interactions, contributing to a more comprehensive understanding of cellular function and pathology.

The significance of RAB1B Gene Knockout Cell Lines cannot be overstated, particularly in biomedical research and clinical applications. They serve as vital tools for investigating diseases related to protein misfolding and trafficking disorders, such as certain neurodegenerative diseases, diabetes, and congenital disorders. Furthermore, these models can be used to screen potential therapeutic agents or understand the molecular basis of drug resistance.

Compared to traditional methods of studying gene function, these knockout cell lines present several advantages. They allow for the maintenance of a controlled genetic background, ensuring that observed effects are attributed specifically to the absence of the RAB1B gene. Additionally, these cell lines can be easily handled and propagated in the laboratory, providing a cost-effective solution for long-term studies.

For researchers and clinicians, investing in RAB1B Gene Knockout Cell Lines means gaining access to a reliable and precise tool that can accelerate discoveries in molecular biology and therapeutic development. By choosing our product, users benefit from our company’s extensive expertise in cellular model development, ensuring high-quality, reproducible results that are essential for pioneering research and clinical outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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