Gene: RAB14
Official Full Name: RAB14, member RAS oncogene familyprovided by HGNC
Gene Summary: RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07401 | RAB14 Knockout cell line (HeLa) | Human | RAB14 | 1:3~1:6 | Negative | Online Inquiry |
KO07402 | RAB14 Knockout cell line (HCT 116) | Human | RAB14 | 1:2~1:4 | Negative | Online Inquiry |
KO07403 | RAB14 Knockout cell line (HEK293) | Human | RAB14 | 1:3~1:6 | Negative | Online Inquiry |
KO07404 | RAB14 Knockout cell line (A549) | Human | RAB14 | 1:3~1:4 | Negative | Online Inquiry |
RAB14 Gene Knockout Cell Lines are genetically engineered cell lines designed for the specific ablation of the RAB14 gene, a crucial player in various cellular processes, including vesicle trafficking and autophagy. By utilizing CRISPR/Cas9 technology, these cell lines provide a robust platform for researchers to dissect the biological functions of RAB14 and its implications in diseases such as cancer and neurodegenerative disorders.
The primary mechanism of action of RAB14 gene knockout cell lines involves the precise targeting of the RAB14 gene sequence, leading to the introduction of mutations that disrupt its normal expression and function. This results in the loss of RAB14 protein, thereby enabling researchers to analyze the effects of its absence on cellular processes such as membrane dynamics, protein sorting, and metabolic pathways. The ability to monitor these processes allows for detailed studies into the molecular pathways that may be impacted by RAB14 deficiency.
Scientifically, RAB14 is implicated in a range of critical functions, making its knockout particularly valuable in both basic and applied research. Its role in disease pathways opens avenues for uncovering novel therapeutic targets in oncology and neurology, thus holding promise for advancing treatment strategies.
Compared to traditional gene knockdown approaches, RAB14 Gene Knockout Cell Lines offer permanent gene disruption, allowing for more reliable and reproducible experiments that are essential for publishing high-quality research. Unlike RNA interference methods that may exhibit transient effects, these knockout cell lines facilitate prolonged studies, providing a more stable model for understanding gene function and interaction.
The value of RAB14 Gene Knockout Cell Lines lies in their ability to contribute profoundly to scientific knowledge regarding cellular mechanisms and pathologies, ultimately driving innovation in drug development and disease management. Researchers and clinicians can leverage these tools to gain valuable insights that could shape future therapeutic interventions.
With a commitment to excellence and cutting-edge biotechnology, our company specializes in providing high-quality biological products, including RAB14 Gene Knockout Cell Lines, to empower researchers in their quest for scientific discovery and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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