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RAB11FIP4 Knockout Cell Lines

Gene: RAB11FIP4

Official Full Name: RAB11 family interacting protein 4provided by HGNC

Gene Summary: The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24879 RAB11FIP4 Knockout cell line (HCT 116) Human RAB11FIP4 1:2~1:4 Negative Online Inquiry
KO24880 RAB11FIP4 Knockout cell line (HEK293) Human RAB11FIP4 1:3~1:6 Negative Online Inquiry
KO24881 RAB11FIP4 Knockout cell line (A549) Human RAB11FIP4 1:3~1:4 Negative Online Inquiry

Background

RAB11FIP4 Gene Knockout Cell Lines are advanced cellular models specifically designed to facilitate the study of the RAB11FIP4 gene's role in cellular processes, particularly those related to vesicle trafficking and endosomal recycling. These genetically modified cell lines enable researchers to observe the phenotypic consequences of RAB11FIP4 gene disruption, thereby offering a unique platform for investigating its impact on various physiological and pathological contexts.

The primary mechanism of action of RAB11FIP4 involves its participation in the regulation of vesicle transport and membrane trafficking. This protein acts as a linker between RAB11 proteins and the downstream effectors necessary for the transport of cargoes to their ultimate destinations within the cell. By generating knockout cell lines, researchers can explore how a lack of this protein alters vesicle dynamics and affects critical processes such as cytokinesis, immune response, and membrane recycling.

The scientific importance of these cell lines extends to both research and clinical applications. In laboratory settings, they provide valuable insights into diseases related to dysfunctional vesicle trafficking, such as cancer and metabolic disorders. Additionally, they represent a crucial tool for drug discovery, enabling the identification of therapeutic targets and the development of novel treatment strategies.

Compared to alternative models such as overexpression systems or non-specific knockdown technologies, RAB11FIP4 Gene Knockout Cell Lines offer precise gene editing capabilities that enhance the reliability and reproducibility of experimental outcomes. Researchers benefit from the specificity of knockout methodologies, allowing for a clearer interpretation of gene function and delineation of complex biological pathways.

For researchers and clinicians alike, the ability to utilize RAB11FIP4 knockout models is invaluable. It enhances the exploration of critical cellular mechanisms, accelerates the drug discovery process, and fosters a deeper understanding of diseases tied to cellular signaling and transport mechanisms.

At the forefront of genetic innovation, our company specializes in providing high-quality gene knockout cell lines, backed by a wealth of expertise in molecular biology and genetic engineering. By choosing RAB11FIP4 Gene Knockout Cell Lines, you equip your research with a powerful tool that can drive the next breakthroughs in cellular biology and therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

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