Gene: Prlr
Official Full Name: prolactin receptorprovided by MGI
Gene Summary: Enables prolactin receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cell surface receptor signaling pathway via JAK-STAT; mammary gland development; and prostate gland growth. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and limb segment. Used to study familial medullary thyroid carcinoma. Human ortholog(s) of this gene implicated in hyperprolactinemia. Orthologous to human PRLR (prolactin receptor). [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01141 | Prlr Knockout cell line(HT22) | Mouse | Prlr | 1:3-1:5 | Negative | Online Inquiry |
Prlr Gene Knockout Cell Lines are specialized cellular models in which the prolactin receptor (Prlr) gene has been deliberately disrupted or "knocked out". This innovative tool allows researchers to investigate the multifaceted roles of prolactin, a hormone critical for lactation, reproductive functions, and several metabolic processes. By investigating Prlr-deficient cell lines, scientists can delineate the signaling pathways influenced by prolactin, providing insights into both physiological and pathological conditions where prolactin signaling might play a pivotal role.
The primary function of these knockout cell lines lies in their ability to elucidate the mechanistic underpinnings associated with Prlr activity. By creating a cellular environment devoid of the prolactin receptor, researchers can easily assess the biological consequences of its absence on cellular growth, differentiation, and response to hormonal stimuli. This approach enhances our understanding of prolactin-related disorders, such as certain cancers, infertility issues, and metabolic syndromes, paving the way for targeted therapeutic interventions.
From a scientific standpoint, Prlr Gene Knockout Cell Lines offer invaluable applications in various research domains including endocrinology, oncology, and reproductive biology. Utilizing these cell lines allows for high-throughput screening of potential pharmacological agents that target prolactin signaling, making them indispensable for drug discovery platforms.
Compared to alternative models, these knockout cell lines present unique advantages, including enhanced specificity in studying the prolactin signaling pathways without the confounding effects of receptor activity. Additionally, they can be readily modified for stable transfection or gene editing applications, providing a versatile platform for further research.
Researchers and clinicians will find that these Prlr Gene Knockout Cell Lines are not only a vital resource for advancing our understanding of hormonal signaling but also a step towards developing novel therapeutic strategies. The precise manipulation of cellular pathways in these models is invaluable for experimental reproducibility and relevance.
Our company prides itself on a commitment to excellence in cellular model development. With extensive expertise in creating cutting-edge biological products, we are dedicated to providing researchers with the tools they need to make groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.