Gene: PZP
Official Full Name: PZP alpha-2-macroglobulin likeprovided by HGNC
Gene Summary: The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. [provided by RefSeq, Dec 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35732 | PZP Knockout cell line (HeLa) | Human | PZP | 1:3~1:6 | Negative | Online Inquiry |
PZP Gene Knockout Cell Lines are a sophisticated tool created for precise genetic research and high-quality functional studies. These engineered cell lines are specifically designed to harbor targeted deletions of the PZP gene (Pregnancy Zone Protein), enabling researchers to investigate the gene's role in various biological processes and disease states. The knockout approach, achieved through advanced gene-editing technologies like CRISPR/Cas9, allows scientists to produce cells that lack the functional gene, thereby aiding in the elucidation of gene function and its implications in health and disease.
Key mechanisms of action for these cell lines involve the elimination of PZP protein production, allowing for detailed studies on the cellular and molecular consequences of its absence. Such investigations are crucial for understanding the pathways influenced by PZP, including its roles in immune modulation and pregnancy. The availability of these knockout lines enhances research capabilities, providing a valuable platform for drug discovery, disease modeling, and therapeutic development.
In clinical and research environments, PZP Gene Knockout Cell Lines stand out due to their reliability and reproducibility, which are pivotal for generating consistent experimental results. Unlike alternatives that may rely on transient knockdown methods or unregulated expression systems, these stable knockout lines ensure persistent and predictable gene inactivation, which is vital for long-term studies.
The intrinsic value of the PZP Gene Knockout Cell Lines lies in their capacity to facilitate significant advancements in our understanding of genetic functions, edge into therapeutic development, and ultimately improve outcomes in clinical settings. Researchers and clinicians can leverage these tools to gain deeper insights into the genetic basis of diseases and to explore novel intervention strategies.
Our company is dedicated to advancing scientific research through high-quality biological products and has a proven track record of supporting innovative research endeavors. With a strong commitment to delivering exceptional genetic tools, we empower researchers to push the boundaries of their investigations, ultimately contributing to scientific progress and better health outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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