Gene: PTPRU
Official Full Name: protein tyrosine phosphatase receptor type Uprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32325 | PTPRU Knockout cell line (HeLa) | Human | PTPRU | 1:3~1:6 | Negative | Online Inquiry |
KO32326 | PTPRU Knockout cell line (HCT 116) | Human | PTPRU | 1:2~1:4 | Negative | Online Inquiry |
KO32327 | PTPRU Knockout cell line (HEK293) | Human | PTPRU | 1:3~1:6 | Negative | Online Inquiry |
KO32328 | PTPRU Knockout cell line (A549) | Human | PTPRU | 1:3~1:4 | Negative | Online Inquiry |
PTPRU Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the PTPRU gene, a member of the protein tyrosine phosphatase (PTP) family that plays a significant role in cellular signaling processes. By employing advanced CRISPR-Cas9 technology, these knockout cell lines facilitate the study of PTPRU's functional contributions in various biological contexts, particularly in tumor biology and immune response mechanisms.
The primary function of the PTPRU gene involves the regulation of cellular pathways related to cell adhesion, proliferation, and differentiation. By disrupting these pathways, researchers can observe the downstream effects on cellular behavior, providing insights into the gene's role in cancer progression or the immune system's response to pathogens. This mechanism of action is critical for understanding both basic biological processes and disease states where PTPRU dysregulation may be implicated.
From a scientific perspective, PTPRU Gene Knockout Cell Lines offer invaluable tools for researchers in both academic and clinical settings. They allow for targeted investigations into the particular functions of PTPRU, unraveling its influence on various diseases or therapeutic responses. These lines serve as essential models for high-throughput drug screening, gene therapy developments, and biomarker identification, showcasing their versatility and relevance in translational research.
One of the critical advantages of our PTPRU Gene Knockout Cell Lines is their rigorous validation and characterization, ensuring consistency and reproducibility in experiments. Compared to alternative models, our cell lines are optimized for ease of use and are accompanied by extensive documentation and support, enabling researchers to achieve rapid experimental outcomes.
For researchers and clinicians alike, these knockout cell lines represent a transformative resource for advancing understanding in cellular signaling and disease mechanisms. By choosing our PTPRU Gene Knockout Cell Lines, users gain access to a scientifically robust platform developed by our experienced team, dedicated to advancing biological research and the development of innovative solutions for better health outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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