Gene: PTPRJ
Official Full Name: protein tyrosine phosphatase receptor type Jprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04183 | PTPRJ Knockout cell line (HeLa) | Human | PTPRJ | 1:3~1:6 | Negative | Online Inquiry |
KO04184 | PTPRJ Knockout cell line (HCT 116) | Human | PTPRJ | 1:2~1:4 | Negative | Online Inquiry |
KO04185 | PTPRJ Knockout cell line (HEK293) | Human | PTPRJ | 1:3~1:6 | Negative | Online Inquiry |
KO04186 | PTPRJ Knockout cell line (A549) | Human | PTPRJ | 1:3~1:4 | Negative | Online Inquiry |
PTPRJ Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to enable researchers to study the functional role of the PTPRJ gene, a protein-tyrosine phosphatase implicated in various biological processes, including cell signaling, migration, and differentiation. By creating knockout versions of these cell lines, researchers can effectively eliminate the expression of the PTPRJ gene, thereby allowing for detailed investigations of the downstream effects of its absence.
These cell lines function through a systematic gene-editing approach, often utilizing CRISPR/Cas9 technology to ensure precise targeting and disruption of the PTPRJ gene. The resultant knockout cells provide a robust platform for understanding the gene’s contributions to cellular pathways, such as immune responses and tumorigenesis. With this, scientists can elucidate the mechanisms by which PTPRJ influences pathophysiological conditions, including cancer progression and chronic inflammatory diseases.
The scientific importance of PTPRJ Gene Knockout Cell Lines extends to both basic research and clinical applications. They serve as a critical tool in drug discovery, genetic studies, and biomarker identification, enabling the exploration of therapeutic avenues that may target specific signaling pathways interrupted by PTPRJ dysregulation.
One key advantage of these knockout cell lines is their availability for high-throughput screening, facilitating the identification of compounds that can modulate PTPRJ activity. Additionally, they offer a standardized and reproducible model system that surpasses traditional overexpression models, which can often lead to unintended phenotypic alterations. This unique selling point is crucial for researchers aiming for authenticity in their experimental outcomes.
For researchers and clinicians dedicated to unraveling the complexities of cell signaling and disease mechanisms, PTPRJ Gene Knockout Cell Lines represent a valuable asset. They not only provide insight into gene function but also pave the way for impactful advancements in therapeutic development.
Our company's commitment to quality and innovation reinforces our expertise in producing reliable genetic tools tailored to the needs of the scientific community. With PTPRJ Gene Knockout Cell Lines, we continue to support groundbreaking research aimed at advancing human health.
Please note that all services are for research use only. Not intended for any clinical use.
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