Gene: PTPN13
Official Full Name: protein tyrosine phosphatase non-receptor type 13provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04378 | PTPN13 Knockout cell line (HeLa) | Human | PTPN13 | 1:3~1:6 | Negative | Online Inquiry |
KO04379 | PTPN13 Knockout cell line (HCT 116) | Human | PTPN13 | 1:2~1:4 | Negative | Online Inquiry |
KO04380 | PTPN13 Knockout cell line (HEK293) | Human | PTPN13 | 1:3~1:6 | Negative | Online Inquiry |
KO04381 | PTPN13 Knockout cell line (A549) | Human | PTPN13 | 1:3~1:4 | Negative | Online Inquiry |
PTPN13 Gene Knockout Cell Lines are specialized, genetically engineered cell lines that facilitate the study of the PTPN13 gene, which encodes a member of the protein tyrosine phosphatase family, known to play a crucial role in cell signaling pathways. These knockout models are specifically designed to be deficient in the expression of PTPN13, allowing researchers to investigate the implications of PTPN13 deficiency in cellular processes such as proliferation, migration, and apoptosis.
The primary mechanism behind the functionality of these cell lines involves the complete ablation of PTPN13 protein production, enabling the analysis of signaling cascades that are modulated by this phosphatase. By observing changes in cellular behavior and gene expression in the absence of PTPN13, researchers can gain insights into its role in various conditions, including cancer development and progression, as well as potential metabolic disorders. Furthermore, these knockout models serve as a critical tool in the validation of therapeutic targets and drug responses.
In scientific research, PTPN13 has been linked to several significant pathways, which underscores its importance in understanding disease mechanisms, particularly in the context of tumor biology. The development of therapeutic strategies aimed at restoring or modulating PTPN13 function could have far-reaching implications in clinical settings, particularly for precision medicine approaches.
One of the key advantages of the PTPN13 Gene Knockout Cell Lines is their specificity and reliability compared to conventional methods of gene silencing, such as RNA interference, which may have off-target effects. Additionally, these cell lines provide a stable genetic background that is crucial for reproducibility in experiments. Researchers will appreciate the ease of use and the robust performance of these knockout models, making them indispensable for studies involving the PTPN13 gene.
Given our company’s expertise in developing high-quality genetic models, we offer unparalleled support and resources to ensure that our customers can fully leverage the capabilities of PTPN13 Gene Knockout Cell Lines in their projects. Our commitment to advancing research through innovative biological products positions us as a leader in the field, dedicated to meeting the needs of researchers and clinicians alike.
Please note that all services are for research use only. Not intended for any clinical use.
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