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PTGER2 Knockout Cell Lines

Gene: PTGER2

Official Full Name: prostaglandin E receptor 2provided by HGNC

Gene Summary: This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07592 PTGER2 Knockout cell line (HCT 116) Human PTGER2 1:2~1:4 Negative Online Inquiry
KO07593 PTGER2 Knockout cell line (HEK293) Human PTGER2 1:3~1:6 Negative Online Inquiry

Background

PTGER2 Gene Knockout Cell Lines are innovative biological tools designed for researchers focused on studying the role of the prostaglandin E2 receptor subtype 2 (PTGER2) in various biological processes. These cell lines have been genetically engineered to lack the expression of the PTGER2 gene, facilitating the investigation of its functions in signaling pathways and disease mechanisms. By enabling precise manipulation of this receptor, researchers can delve into how PTGER2 interacts with its endogenous pathways, impacting inflammatory responses, cancer progression, and various cardiovascular conditions.

The mechanism of action for these knockout cell lines involves the genomic editing of the PTGER2 locus, typically achieved via CRISPR/Cas9 technology or other targeted gene editing strategies. This precise modification allows for the study of the receptor's absence and its subsequent physiological consequences within various cellular contexts. The resulting cell lines are invaluable for elucidating the receptor's role in mediating cellular responses to prostaglandins, thereby contributing to a deeper understanding of complex signaling networks.

Scientifically, PTGER2 Gene Knockout Cell Lines hold significant potential in both research and clinical applications. They serve as powerful models for deciphering the intricate biology associated with PTGER2, informing drug development efforts, and advancing therapeutic strategies for conditions such as asthma, rheumatoid arthritis, and cancer. As the role of prostaglandins becomes more apparent in various diseases, these cell lines will be instrumental in the discovery of novel therapeutic targets.

Compared to conventional cell lines, PTGER2 Gene Knockout Cell Lines offer unparalleled specificity by enabling researchers to directly assess the physiological role of PTGER2 without compensatory mechanisms often seen in less targeted models. Moreover, the ability to study these knockout lines in diverse cellular environments enriches the experimental data, providing a robust platform for hypothesis-driven research.

Researchers and clinicians will find tremendous value in these knockout cell lines as they embody both innovative gene-editing technology and the burgeoning understanding of prostaglandin biology. The unique insights gained through the use of PTGER2 Gene Knockout Cell Lines can expedite the pathway from basic discovery to clinical application, ultimately enhancing patient outcomes.

At [Your Company Name], we pride ourselves on being at the forefront of genetic engineering technologies, continuously offering products that meet the evolving needs of the scientific community. Our commitment to quality and innovation ensures that our PTGER2 Gene Knockout Cell Lines will serve as a reliable and groundbreaking resource in your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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