Gene: PSPC1
Official Full Name: paraspeckle component 1provided by HGNC
Gene Summary: This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14815 | PSPC1 Knockout cell line (HeLa) | Human | PSPC1 | 1:3~1:6 | Negative | Online Inquiry |
KO14816 | PSPC1 Knockout cell line (HCT 116) | Human | PSPC1 | 1:2~1:4 | Negative | Online Inquiry |
KO14817 | PSPC1 Knockout cell line (HEK293) | Human | PSPC1 | 1:3~1:6 | Negative | Online Inquiry |
KO14818 | PSPC1 Knockout cell line (A549) | Human | PSPC1 | 1:3~1:4 | Negative | Online Inquiry |
PSPC1 Gene Knockout Cell Lines are meticulously engineered cellular models in which the PSPC1 gene has been deliberately disrupted. This gene encodes a multifunctional protein involved in various cellular processes, including RNA metabolism and cellular signaling. The creation of these knockout cell lines allows researchers to study the precise biological roles of the PSPC1 protein, determining its implications in cellular function and disease states.
The primary function of these knockout cell lines is to facilitate the investigation of gene function by observing the resultant phenotypic effects stemming from the absence of the PSPC1 gene. Upon removal, critical pathways may alter, providing insights into gene interaction networks and cellular pathways. This allows researchers to dissect complex biological mechanisms, identify potential targets for therapeutic intervention, and elucidate disease pathways related to cell proliferation, differentiation, and apoptosis.
In terms of scientific importance, PSPC1 Gene Knockout Cell Lines have significant applications in both basic research and clinical settings. They are particularly valuable for investigating cancer biology, neurodegenerative diseases, and other disorders where PSPC1 expression might be aberrant. Furthermore, these models can be used in drug discovery processes, aiding in the identification of novel therapeutic compounds that can modulate PSPC1-related pathways.
What sets our PSPC1 Gene Knockout Cell Lines apart from alternatives is their high specificity and reproducibility. Our rigorous selection process ensures that each line maintains genetic integrity and functionality while facilitating easy application in various experimental setups. Additionally, the extensive characterization of these cell lines guarantees that researchers can rely on consistent data, minimizing the variability often seen with other models.
Investing in PSPC1 Gene Knockout Cell Lines translates into invaluable advantages for researchers and clinicians alike, enabling exploration into gene function that can lead to advancements in understanding and treating complex diseases. Our company is committed to providing high-quality biological products and cutting-edge cellular models, supported by a wealth of expertise in genetic biotechnologies. By choosing our knockout cell lines, users are assured of accessing top-tier scientific resources aimed at fostering groundbreaking research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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