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PRR14 Knockout Cell Lines

Gene: PRR14

Official Full Name: proline rich 14provided by HGNC

Gene Summary: The protein encoded by this gene tethers heterochromatin to the nuclear laminar scaffold by binding heterochromatin protein 1 (HP1) and the nuclear lamina. The tether is broken during mitosis and reforms quickly after mitosis, with the encoded protein first binding HP1 and then attaching to the nuclear lamina. This protein also has been shown to promote MyoD activity and skeletal myogenesis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14857 PRR14 Knockout cell line (HeLa) Human PRR14 1:3~1:6 Negative Online Inquiry
KO14858 PRR14 Knockout cell line (HCT 116) Human PRR14 1:2~1:4 Negative Online Inquiry
KO14859 PRR14 Knockout cell line (HEK293) Human PRR14 1:3~1:6 Negative Online Inquiry
KO14860 PRR14 Knockout cell line (A549) Human PRR14 1:3~1:4 Negative Online Inquiry

Background

PRR14 Gene Knockout Cell Lines are specially engineered cell lines that have been modified to remove the expression of the PRR14 gene, a critical component involved in various cellular processes, including chromatin remodeling and cell cycle regulation. These knockout models serve as vital tools in molecular biology and genetic research, providing insights into the role of PRR14 in cellular function and disease mechanisms.

The primary function of PRR14 is to facilitate the organization and maintenance of the nuclear architecture, influencing gene expression patterns and cellular proliferation. By using these knockout cell lines, researchers can investigate the specific pathways and biological functions mediated by PRR14, offering a window into its role in diseases such as cancer, where aberrant cell cycle control is a hallmark. The mechanisms at play can be explored through various assays, including knockdown studies, gene expression profiling, and functional assays, allowing for a comprehensive understanding of how PRR14 contributes to overall cellular health.

Scientifically, PRR14 Gene Knockout Cell Lines are instrumental for both academic and clinical research applications. They enable exploration into potential therapeutic targets, facilitate drug discovery, and help elucidate the underlying genetic interactions that drive complex diseases. Researchers gain an edge in translational studies where understanding gene function is essential for the development of innovative therapies.

What sets our PRR14 Gene Knockout Cell Lines apart from alternatives on the market is their robust validation, ease of use, and reproducibility across multiple research settings. Each cell line is meticulously characterized to ensure consistent results, providing researchers with confidence in their experimental outcomes. This reliability, paired with customizable options for specific research needs, makes our cell lines a preferred choice among scientists and clinicians alike.

In an ever-evolving field of biological research, our company prides itself on its commitment to advancing scientific discovery through high-quality, engineered biological products. With our extensive expertise in genetic manipulation and cell line development, we deliver products that empower researchers to unlock new dimensions of understanding and innovation in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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