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PRPS1 Knockout Cell Lines

Gene: PRPS1

Official Full Name: phosphoribosyl pyrophosphate synthetase 1provided by HGNC

Gene Summary: This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06246 PRPS1 Knockout cell line (HeLa) Human PRPS1 1:3~1:6 Negative Online Inquiry
KO06247 PRPS1 Knockout cell line (HCT 116) Human PRPS1 1:2~1:4 Negative Online Inquiry
KO06248 PRPS1 Knockout cell line (HEK293) Human PRPS1 1:3~1:6 Negative Online Inquiry
KO06249 PRPS1 Knockout cell line (A549) Human PRPS1 1:3~1:4 Negative Online Inquiry

Background

PRPS1 Gene Knockout Cell Lines are genetically engineered cell models that have had the PRPS1 gene specifically disrupted through targeted gene editing technologies such as CRISPR-Cas9. This product allows researchers to study the functional consequences of PRPS1 deletion, a gene that plays a pivotal role in purine metabolism and nucleotide synthesis. By creating PRPS1 knockout cell lines, scientists can closely examine the molecular pathways affected by the absence of this gene, providing insights into its role in various biological processes and diseases.

The key function of these knockout cell lines is to serve as a platform for investigating the metabolic alterations and physiological changes that occur without the PRPS1 gene. As PRPS1 is integral to the synthesis of purine nucleotides, the knockout lines can help elucidate the impacts on cell proliferation, apoptosis, and overall cellular health, making them invaluable for studying conditions such as cancer, neurodegeneration, and metabolic disorders.

In both research and clinical settings, PRPS1 knockout cell lines are critically important for validating drug targets, exploring gene function, and understanding disease mechanisms. Their specificity offers researchers a powerful tool to dissect the pathways involved in nucleotide metabolism, thereby fostering the development of therapeutic strategies aimed at correcting or compensating for the effects of PRPS1 deficiency.

Compared to conventional cell lines, the unique selling points of PRPS1 knockout cell lines include their precise genetic modification, which allows for more reliable and reproducible experimental outcomes. Furthermore, these cell lines can be employed in high-throughput screening assays, facilitating rapid evaluation of potential therapeutic compounds targeting PRPS1-related pathways.

For researchers and clinicians, the value of PRPS1 knockout cell lines lies not only in their ability to provide a deeper understanding of fundamental biological processes but also in their potential to drive innovation in the development of targeted therapies. Our company is dedicated to providing high-quality biological products supported by extensive research and expertise in genetic engineering, ensuring that our customers have access to cutting-edge tools for advancing their work in life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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