Gene: PROM1
Official Full Name: prominin 1provided by HGNC
Gene Summary: This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03699 | PROM1 Knockout cell line (HCT 116) | Human | PROM1 | 1:2~1:4 | Negative | Online Inquiry |
PROM1 Gene Knockout Cell Lines represent a cutting-edge biological tool engineered to provide deeper insights into the functional mechanisms of the PROM1 gene, which encodes the protein prominin-1, an important player in stem cell biology and cancer research. These cell lines are generated through advanced CRISPR-Cas9 gene-editing technology, effectively disrupting the PROM1 gene, thus allowing researchers to investigate the consequences of its absence.
The primary function of the PROM1 Gene Knockout Cell Lines is to facilitate studies on cellular differentiation, proliferation, and signaling pathways that are influenced by prominin-1. By creating a controlled environment where the PROM1 gene is knocked out, researchers can accurately observe alterations in cellular behavior, enabling them to unravel the complexities of stem cell maintenance and tumorigenesis. This mechanistic understanding is crucial, as it may lead to the identification of novel therapeutic targets for regenerative medicine and cancer treatments.
In the scientific arena, these cell lines play a vital role in advancing research on various conditions, including neurodegenerative diseases and cancer, where PROM1 expression is often implicated. Their application is invaluable in drug discovery and development, providing a reliable model for screening potential therapeutics that target the molecular pathways influenced by PROM1.
What sets the PROM1 Gene Knockout Cell Lines apart from alternatives is their high specificity and efficiency in gene editing, coupled with rigorous validation processes to ensure the accuracy and reliability of findings. Unlike traditional knockout models, which may exhibit mixed or incomplete knockouts, our cell lines guarantee robust gene disruption, paving the way for unambiguous experimental results.
For researchers and clinicians alike, the PROM1 Gene Knockout Cell Lines offer an unprecedented opportunity to elucidate gene function within a specific context, thereby driving forward innovations in both basic and applied biomedical research. Our company's extensive expertise in genetic engineering and commitment to providing high-quality biological products ensure that these cell lines meet the highest standards, empowering users to achieve impactful discoveries in their respective fields.
Please note that all services are for research use only. Not intended for any clinical use.
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