Gene: PRMT6
Official Full Name: protein arginine methyltransferase 6provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05709 | PRMT6 Knockout cell line (HeLa) | Human | PRMT6 | 1:3~1:6 | Negative | Online Inquiry |
KO05710 | PRMT6 Knockout cell line (HCT 116) | Human | PRMT6 | 1:2~1:4 | Negative | Online Inquiry |
KO05711 | PRMT6 Knockout cell line (HEK293) | Human | PRMT6 | 1:3~1:6 | Negative | Online Inquiry |
PRMT6 Gene Knockout Cell Lines are specialized cell lines developed through the precise editing of the protein arginine methyltransferase 6 (PRMT6) gene, utilizing advanced CRISPR-Cas9 technology. This innovative product allows researchers to explore the functional role of PRMT6 in various biological processes and disease models, particularly its implications in gene regulation, cell signaling, and chromatin remodeling. The knockout of PRMT6 can lead to significant alterations in arginine methylation, influencing a myriad of downstream cellular functions, including transcriptional control and response to stress.
The key function of these knockout cell lines lies in their ability to facilitate the study of PRMT6's role in epigenetic regulation and its potential contributions to diseases such as cancer and neurodegenerative disorders. By providing a stable and reproducible model system, these cell lines enable researchers to dissect the intricate pathways regulated by PRMT6, providing invaluable insights that are critical for understanding cellular mechanisms and developing targeted therapies.
Scientifically, the applications of PRMT6 Gene Knockout Cell Lines extend beyond basic research; they are invaluable in preclinical studies aimed at identifying novel therapeutic targets. Their unique advantage over other genetic models is their precise gene editing, resulting in a more predictable and stable expression profile that enhances experimental reproducibility.
By utilizing PRMT6 Gene Knockout Cell Lines, researchers and clinicians can engage in cutting-edge studies that offer a deeper understanding of epigenetic modifications in health and disease. They provide an exceptional value to laboratories focused on molecular biology, oncology, and drug discovery, enabling significant advancements in therapeutic developments.
Our company has a proven track record in producing high-quality genetic tools and cell lines that empower researchers with reliable and innovative products. With PRMT6 Gene Knockout Cell Lines, we continue our commitment to advancing the scientific community and improving research outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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