Gene: PRKCI
Official Full Name: protein kinase C iotaprovided by HGNC
Gene Summary: This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08650 | PRKCI Knockout cell line (HeLa) | Human | PRKCI | 1:3~1:6 | Negative | Online Inquiry |
KO08651 | PRKCI Knockout cell line (HCT 116) | Human | PRKCI | 1:2~1:4 | Negative | Online Inquiry |
KO08652 | PRKCI Knockout cell line (HEK293) | Human | PRKCI | 1:3~1:6 | Negative | Online Inquiry |
KO08653 | PRKCI Knockout cell line (A549) | Human | PRKCI | 1:3~1:4 | Negative | Online Inquiry |
PRKCI Gene Knockout Cell Lines are genetically engineered cellular models that facilitate the study of the PRKCI gene, known for its involvement in various cellular processes including survival and proliferation. Through CRISPR-Cas9 technology, these cell lines have been meticulously designed to exhibit complete knockout of the PRKCI gene, thereby allowing researchers to examine the physiological and pathological roles attributed to its loss.
One of the key functions of these cell lines is their ability to provide insights into PRKCI's regulatory mechanisms within signal transduction pathways, particularly relating to cancer and metabolic disorders. By utilizing these knockout models, researchers can study the impact of PRKCI absence on cellular behavior, interactions with other signaling molecules, and potential compensatory mechanisms that come into play.
The scientific importance of PRKCI Gene Knockout Cell Lines spans across various domains of biomedical research, particularly in oncology, where understanding the gene's contribution to tumorigenesis can inform targeted therapies. These models are invaluable in preclinical studies for drug discovery and in assessing the efficacy of therapeutic approaches aimed at diseases linked to PRKCI dysregulation.
Compared to traditional methods of gene silencing, such as siRNA or shRNA approaches, the use of knockout cell lines offers a more thorough and permanent solution for gene functional studies, eliminating any off-target effects associated with transient knockdown. This permanence allows for more consistent data collection and analysis across experimental replications.
For researchers and clinicians, the value of PRKCI Gene Knockout Cell Lines lies not only in their ability to support groundbreaking research but also in their potential to accelerate the development of therapies that target PRKCI-associated diseases. Our company prides itself on delivering high-quality, validated cell lines backed by expert support, ensuring that your research endeavors are grounded in reliable and reproducible data.
Please note that all services are for research use only. Not intended for any clinical use.
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