Gene: PRDM8
Official Full Name: PR/SET domain 8provided by HGNC
Gene Summary: This gene encodes a protein that belongs to a conserved family of histone methyltransferases that predominantly act as negative regulators of transcription. The encoded protein contains an N-terminal Su(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain and a double zinc-finger domain. Knockout of this gene in mouse results in mistargeting by neurons of the dorsal telencephalon, abnormal itch-like behavior, and impaired differentiation of rod bipolar cells. In humans, the protein has been shown to interact with the phosphatase laforin and the ubiquitin ligase malin, which regulate glycogen construction in the cytoplasm. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14907 | PRDM8 Knockout cell line (HEK293) | Human | PRDM8 | 1:3~1:6 | Negative | Online Inquiry |
PRDM8 Gene Knockout Cell Lines are genetically modified cellular models designed to specifically disrupt the PRDM8 gene, a member of the PRDM family characterized by its role in cell differentiation and development. By creating a knockout of this gene, researchers can investigate the functional significance of PRDM8 within diverse biological pathways, particularly those involving neuronal and non-neuronal lineage specification.
The key function of these knockout cell lines involves the loss of PRDM8 protein expression, which serves as a transcriptional regulator that can influence gene expression patterns crucial for cellular processes such as proliferation, migration, and apoptosis. The mechanism of action allows users to study the phenotypic changes arising from the ablation of this gene, employing advanced techniques like CRISPR/Cas9 gene editing, which provides precise and efficient gene disruption. As a result, these cell lines offer an invaluable tool for elucidating the role of PRDM8 in various pathophysiological conditions, including neural development disorders and cancers.
The scientific importance of PRDM8 Gene Knockout Cell Lines extends to numerous applications within both research and clinical settings. They serve as a vital asset for drug discovery, functional genomics, and the study of gene regulatory networks, providing insights that may lead to novel therapeutic strategies. Compared to traditional methods of gene manipulation, these knockout models offer enhanced specificity and reproducibility, making them superior tools for researchers seeking to decode complex biological systems.
The unique selling points of PRDM8 Gene Knockout Cell Lines lie in their ability to facilitate comprehensive analyses of the PRDM8 gene's role in various cellular contexts, allowing for high-throughput screening and validation of therapeutic interventions. Additionally, their ability to mimic specific disease states enables researchers to investigate potential biomarkers and therapeutic targets with greater accuracy.
In conclusion, investing in PRDM8 Gene Knockout Cell Lines represents a strategic advantage for researchers, clinicians, and biotechnology firms aiming to deepen their understanding of gene function and develop innovative treatments. Our company, renowned for its commitment to quality and scientific innovation, provides expertly engineered biological products that meet the evolving needs of the scientific community, driving forward research and clinical advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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