Gene: PRCP
Official Full Name: prolylcarboxypeptidaseprovided by HGNC
Gene Summary: This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35940 | PRCP Knockout cell line (HeLa) | Human | PRCP | 1:3~1:6 | Negative | Online Inquiry |
KO35941 | PRCP Knockout cell line (HCT 116) | Human | PRCP | 1:2~1:4 | Negative | Online Inquiry |
KO35942 | PRCP Knockout cell line (HEK293) | Human | PRCP | 1:3~1:6 | Negative | Online Inquiry |
KO35943 | PRCP Knockout cell line (A549) | Human | PRCP | 1:3~1:4 | Negative | Online Inquiry |
PRCP Gene Knockout Cell Lines are specialized cellular models designed for researchers to study the function of the PRCP (Prolylcarboxypeptidase) gene. These knockout lines are engineered through precise gene editing techniques to remove or disrupt the PRCP gene's expression, thereby allowing for the in-depth analysis of the gene's role in physiological and pathological processes. The key functions of these cell lines include elucidating the impact of PRCP on cellular signaling pathways, metabolism, and disease progression, particularly in cardiovascular and neurological disorders.
The mechanism through which PRCP knockout cell lines operate hinges on the absence of the peptide-cleaving enzyme, which is essential in regulating the levels of bioactive peptides that modulate blood pressure and brain function. By utilizing these cell lines, researchers can not only observe changes in cellular behavior and gene expression resulting from the loss of PRCP, but also explore compensatory mechanisms and identify potential therapeutic targets for drug development.
Scientifically, PRCP Gene Knockout Cell Lines hold significant importance in translational research, offering invaluable insights into the mechanisms underlying diseases and advancing personalized medicine approaches. Compared to other models, these knockout lines provide a more specific and accurate representation of gene function, facilitating more robust experimental outcomes.
The unique selling points of PRCP Gene Knockout Cell Lines lie in their high specificity, reliability, and the capacity to produce reproducible results that other models might fail to achieve. Additionally, using these cell lines can significantly reduce the time and resources spent on experimental validation, making them an efficient choice for researchers and clinicians alike.
In summary, PRCP Gene Knockout Cell Lines are essential tools for those engaged in cutting-edge research and therapeutic development. Our company, with extensive expertise in genetic engineering and cell line development, is dedicated to providing high-quality biological products that empower scientists to push the boundaries of discovery in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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