Gene: PPP4R4
Official Full Name: protein phosphatase 4 regulatory subunit 4provided by HGNC
Gene Summary: The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and appear to function as protein-protein interaction surfaces. The repeat-containing region of this protein has some similarity to the constant regulatory domain of the protein phosphatase 2A PR65/A subunit. The encoded protein binds protein serine/threonine phosphatase 4c in the cytoplasm. [provided by RefSeq, Jan 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14920 | PPP4R4 Knockout cell line (HCT 116) | Human | PPP4R4 | 1:2~1:4 | Negative | Online Inquiry |
KO14921 | PPP4R4 Knockout cell line (HEK293) | Human | PPP4R4 | 1:3~1:6 | Negative | Online Inquiry |
PPP4R4 Gene Knockout Cell Lines are specialized cellular models where the PPP4R4 gene, which encodes a regulatory subunit of protein phosphatase 4, has been strategically disrupted. This gene plays a critical role in various cellular signaling pathways, including those involved in cell division, DNA repair, and stress response. The knockout of PPP4R4 allows researchers to explore the consequences of its absence, particularly regarding the mechanisms involved in cellular homeostasis and proliferation.
These cell lines operate under a well-characterized knockout mechanism, typically utilizing CRISPR-Cas9 technology or homologous recombination to ensure precise gene editing. By eliminating the expression of PPP4R4, the cell lines facilitate the study of downstream effects on phosphatase signaling and provide insights into the cellular behaviors tied to this important regulatory pathway. Researchers can utilize these models to delineate pathways involving cell-cycle regulation, apoptosis, and potential oncogenic processes, thereby shedding light on cancer research and therapeutic targets.
In the context of research and clinical studies, the PPP4R4 Gene Knockout Cell Lines are invaluable. They serve as powerful tools for investigating the role of phosphatases in health and disease and can significantly accelerate drug discovery and development efforts. With an emphasis on precision and reproducibility, these cell lines enhance experimental rigor, making them suitable for both basic research and translational applications.
What sets our PPP4R4 Gene Knockout Cell Lines apart is their high-quality validation and the extensive characterization provided by our team. Unlike other available models, our cell lines come with detailed functional assays, ensuring that users can reliably interpret their research findings. Moreover, the accessibility and user-friendly documentation offer intuitive support to researchers, enabling them to easily incorporate these models into their workflows.
For researchers and clinicians seeking to deepen their understanding of protein phosphatase signaling and its implications in various diseases, the PPP4R4 Gene Knockout Cell Lines represent a crucial resource. Our company prides itself on its expertise in creating and providing high-quality biological products, driven by the mission to empower scientific advancement through innovative solutions.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.