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PPP4R3A Knockout Cell Lines

Gene: PPP4R3A

Official Full Name: protein phosphatase 4 regulatory subunit 3Aprovided by HGNC

Gene Summary: Predicted to enable protein phosphatase activator activity. Predicted to be involved in DNA damage response and regulation of double-strand break repair. Predicted to act upstream of or within positive regulation of gluconeogenesis and protein dephosphorylation. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14926 PPP4R3A Knockout cell line (HeLa) Human PPP4R3A 1:3~1:6 Negative Online Inquiry
KO14927 PPP4R3A Knockout cell line (HCT 116) Human PPP4R3A 1:2~1:4 Negative Online Inquiry
KO14928 PPP4R3A Knockout cell line (HEK293) Human PPP4R3A 1:3~1:6 Negative Online Inquiry
KO14929 PPP4R3A Knockout cell line (A549) Human PPP4R3A 1:3~1:4 Negative Online Inquiry

Background

PPP4R3A Gene Knockout Cell Lines are expertly developed cellular models characterized by the knockout of the PPP4R3A gene, which encodes for a regulatory subunit of protein phosphatase 4, a crucial enzyme involved in various cellular processes such as DNA repair and cell signaling. These cell lines serve as a powerful tool for researchers aiming to elucidate the roles of PPP4R3A in cellular mechanisms, including its impact on cellular proliferation, apoptosis, and response to stressors.

The key functionality of the PPP4R3A knockout is grounded in its ability to disrupt the normal regulatory function of protein phosphatase 4. This disruption allows researchers to investigate the downstream effects of reduced phosphatase activity in various pathways and conditions, providing valuable insights into how aberrant signaling may contribute to disease states. This gene knockout model can reveal specific phenotypic changes, enabling studies into the role of PPP4R3A in cancer biology and other pathologies, making it an invaluable asset in both fundamental and applied research.

The scientific importance of these knockout cell lines extends to numerous applications within research and clinical settings. They can be employed in drug discovery, functional genomics, and studying the molecular basis of diseases linked to PPP4R3A dysregulation. Moreover, their validation in relevant cellular contexts enhances the credibility of findings derived from such studies, thus supporting their potential translational applications.

When compared to alternative models, the PPP4R3A Gene Knockout Cell Lines stand out due to their precise genetic alteration and the ability to generate consistent and reproducible results. These lines are meticulously characterized to ensure their authenticity and reliability, which is essential for producing robust scientific data.

For researchers and clinicians, the use of these specialized cell lines accelerates the understanding of PPP4R3A's biological functions and facilitates the exploration of therapeutic interventions aimed at modulating its activity. The curated expertise of our company in developing and implementing advanced genetic models positions us as a trusted provider in the field of biological research, ensuring that our customers receive high-quality products tailored to their investigative needs.

Please note that all services are for research use only. Not intended for any clinical use.

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