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PPP1CA Knockout Cell Lines

Gene: PPP1CA

Official Full Name: protein phosphatase 1 catalytic subunit alphaprovided by HGNC

Gene Summary: The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08569 PPP1CA Knockout cell line (HeLa) Human PPP1CA 1:3~1:6 Negative Online Inquiry
KO08570 PPP1CA Knockout cell line (HCT 116) Human PPP1CA 1:2~1:4 Negative Online Inquiry
KO08571 PPP1CA Knockout cell line (HEK293) Human PPP1CA 1:3~1:6 Negative Online Inquiry
KO08572 PPP1CA Knockout cell line (A549) Human PPP1CA 1:3~1:4 Negative Online Inquiry

Background

PPP1CA Gene Knockout Cell Lines are genetically engineered cell lines in which the PPP1CA gene, encoding the catalytic subunit of protein phosphatase 1 (PP1), has been inactivated or "knocked out." This innovative product allows researchers to study the biological functions and regulatory mechanisms of PPP1CA in various cellular contexts. By eliminating the expression of this critical gene, scientists can investigate the downstream effects on pathways involving phosphorylation, which is pivotal in regulating a multitude of cellular processes such as cell division, differentiation, and signal transduction.

The primary mechanism enabling this product's functionality is the targeted CRISPR-Cas9 gene editing technology, which provides a high specificity and efficiency in gene knockout. This precision reduces the likelihood of off-target effects, thus ensuring that results can be directly attributed to the absence of PPP1CA. Researchers utilizing these cell lines can delve into the roles of PP1 in conditions such as cancer, neurodegenerative diseases, and metabolic syndromes, thereby contributing invaluable insights that may lead to therapeutic innovations.

PPP1CA Gene Knockout Cell Lines are of significant scientific importance as they enable a deeper understanding of protein phosphorylation regulation and its implications in pathophysiology. They serve as vital tools in both basic research and drug discovery, facilitating the identification of potential therapeutic targets.

One of the unique advantages of using our PPP1CA Gene Knockout Cell Lines is their robust performance in various experimental setups, validated through extensive characterization. Unlike commercially available alternatives, these cell lines are developed with rigorous quality controls and are supported by detailed protocols and assistance for optimal use.

For researchers and clinicians seeking to explore the critical role of protein phosphatases in health and disease, our PPP1CA Gene Knockout Cell Lines represent an invaluable resource. Their reliability and specificity can significantly enhance both experimental accuracy and outcome reproducibility.

As a company with a profound commitment to advancing scientific research, we leverage state-of-the-art genomics and cell biology technologies in developing high-quality biological products. Our expertise ensures that researchers are equipped with tools that foster innovation and contribute to groundbreaking discoveries in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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