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PPM1K Knockout Cell Lines

Gene: PPM1K

Official Full Name: protein phosphatase, Mg2+/Mn2+ dependent 1Kprovided by HGNC

Gene Summary: This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21547 PPM1K Knockout cell line (HeLa) Human PPM1K 1:3~1:6 Negative Online Inquiry
KO21548 PPM1K Knockout cell line (HCT 116) Human PPM1K 1:2~1:4 Negative Online Inquiry
KO21549 PPM1K Knockout cell line (HEK293) Human PPM1K 1:3~1:6 Negative Online Inquiry
KO21550 PPM1K Knockout cell line (A549) Human PPM1K 1:3~1:4 Negative Online Inquiry

Background

PPM1K Gene Knockout Cell Lines are meticulously developed cellular models designed to facilitate the study of the PPM1K gene's role in various biological processes. These cell lines have undergone precise genomic editing to effectively silence the PPM1K gene, providing researchers with an invaluable tool to investigate gene function, signaling pathways, and cellular responses relevant to cancer biology, metabolic disorders, and neurodegenerative diseases.

The key function of the PPM1K gene knockout cell lines lies in their ability to provide insights into the mechanistic pathways associated with PPM1K. This gene encodes a protein involved in dephosphorylating serine/threonine residues, playing a crucial role in regulating various signaling cascades such as MAPK and AKT pathways. By observing the phenotypic changes and molecular alterations induced by the absence of PPM1K, researchers can explore its contributions to cellular processes like proliferation, apoptosis, and differentiation.

In clinical and research applications, these knockout cell lines are pivotal for drug discovery, biomarker identification, and understanding pathogenesis. Their precise modification facilitates high-throughput screening for small molecules that may interact specifically with the pathways influenced by PPM1K, closely mimicking the human condition in an experimental setting.

Advantages of the PPM1K Gene Knockout Cell Lines include rigorous validation of gene editing techniques, consistency in experimental reproducibility, and the ability to study the effects of gene knockout in a controlled environment. Compared to conventional methods like RNA interference, our cell lines provide a permanent and stable alteration at the genomic level, enhancing the reliability of experimental outcomes.

Researchers and clinicians will find these cell lines indispensable in their efforts to uncover novel therapeutic targets and biomarkers. By enabling a deeper understanding of gene function within complex biological systems, PPM1K Gene Knockout Cell Lines are a fundamental resource for advancing biomedical research.

As a leader in producing high-quality biological products, our company leverages advanced genetic engineering techniques and extensive expertise in cell line development. We are committed to providing our customers with the tools necessary for groundbreaking research and discovery in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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