Gene: PPM1F
Official Full Name: protein phosphatase, Mg2+/Mn2+ dependent 1Fprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32989 | PPM1F Knockout cell line (HeLa) | Human | PPM1F | 1:3~1:6 | Negative | Online Inquiry |
KO32990 | PPM1F Knockout cell line (HCT 116) | Human | PPM1F | 1:2~1:4 | Negative | Online Inquiry |
KO32991 | PPM1F Knockout cell line (HEK293) | Human | PPM1F | 1:3~1:6 | Negative | Online Inquiry |
KO32992 | PPM1F Knockout cell line (A549) | Human | PPM1F | 1:3~1:4 | Negative | Online Inquiry |
PPM1F Gene Knockout Cell Lines are genetically modified cell lines that have had the PPM1F gene specifically inactivated, providing a powerful tool for researchers studying the role of this gene in cellular processes. PPM1F, also known as protein phosphatase 2C, is implicated in various biological pathways, including cell signaling, stress response, and regulation of metabolism. By utilizing these knockout cell lines, scientists can effectively analyze the consequences of PPM1F deficiency on cellular behavior, thereby elucidating its functional significance in health and disease.
These cell lines function through the precise removal of the PPM1F gene, which allows for the evaluation of its physiological relevance. When the PPM1F gene is knocked out, downstream signaling pathways and cellular responses can be investigated, leading to a better understanding of disease mechanisms such as cancer and metabolic disorders. Researchers are increasingly relying on gene knockout models to dissect complex biological systems, making PPM1F knockout cell lines a vital component of modern genetics and molecular biology research.
The scientific importance of these cell lines extends into both research and clinical applications, as they can be used to discover potential therapeutic targets and biomarkers for diseases associated with dysregulated PPM1F activity. Compared to other genetic modification techniques, such as CRISPR or RNA interference, knockout cell lines offer stable and consistent gene inactivation, minimizing off-target effects and variability in results.
One unique selling point of PPM1F Gene Knockout Cell Lines is their ease of usage and compatibility with standard cell culture protocols, allowing researchers to integrate them into existing workflows without significant adjustments. Ensuring reproducibility and adaptability, these cell lines significantly enhance experimental robustness, making them an invaluable resource for biological research.
For researchers and clinicians focused on advancing our understanding of molecular mechanisms and developing targeted treatments, the PPM1F Gene Knockout Cell Lines represent a considerable investment in both time and resources. By harnessing these advanced cellular models, users can push the boundaries of current scientific knowledge. Our company prides itself on its commitment to high-quality biological products, expertise in genetic engineering, and understanding of the evolving needs of researchers, ensuring that we provide top-tier tools for exploring the intricate complexities of life at the molecular level.
Please note that all services are for research use only. Not intended for any clinical use.
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