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PPHLN1 Knockout Cell Lines

Gene: PPHLN1

Official Full Name: periphilin 1provided by HGNC

Gene Summary: The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02652 PPHLN1 Knockout cell line (HeLa) Human PPHLN1 1:3~1:6 Negative Online Inquiry
KO02653 PPHLN1 Knockout cell line (HCT 116) Human PPHLN1 1:2~1:4 Negative Online Inquiry
KO02654 PPHLN1 Knockout cell line (HEK293) Human PPHLN1 1:3~1:6 Negative Online Inquiry
KO02655 PPHLN1 Knockout cell line (A549) Human PPHLN1 1:3~1:4 Negative Online Inquiry

Background

PPHLN1 Gene Knockout Cell Lines are specifically engineered cellular models where the PPHLN1 gene has been rendered non-functional through targeted gene editing techniques such as CRISPR/Cas9. These cell lines serve as critical tools for studying the functional role of the PPHLN1 gene, which is implicated in key biological processes including cellular adhesion, proliferation, and response to extracellular signals. By utilizing these knockout cell lines, researchers can elucidate the pathways influenced by PPHLN1, providing insights into its role in various physiological and pathological conditions.

The primary function of the PPHLN1 gene involves its engagement in cell signaling and cytoskeletal organization, vital for maintaining cellular architecture and function. By knocking out this gene, researchers can observe the resultant phenotypic changes, such as alterations in cell morphology, motility, and gene expression profiles, which are essential for understanding disease mechanisms, particularly in cancer research where cell behavior plays a crucial role in tumor proliferation and metastasis.

The scientific importance of PPHLN1 Knockout Cell Lines extends to their applications in both basic and translational research settings. They facilitate the exploration of gene function in mammalian systems, allow for the validation of drug targets, and serve as models to study potential therapeutic interventions. Additionally, these cell lines can be invaluable in preclinical studies, offering a more precise method for evaluating the efficacy of new treatments aiming to manipulate PPHLN1-related pathways.

One of the standout advantages of the PPHLN1 Gene Knockout Cell Lines is their specificity and reliability compared to alternative models such as conventional wild-type cell lines or transiently transfected systems. They provide a stable platform that allows for reproducible experiments, leading to more consistent results. Moreover, these cell lines can be utilized across various applications, including high-throughput screening and functional assays, further enhancing their utility in research.

For researchers and clinicians, the value of PPHLN1 Gene Knockout Cell Lines lies in their ability to accelerate discoveries that can lead to novel therapeutic strategies. This product streamlines experimentation, reducing the time and resources required to investigate gene function. Our company, renowned for its cutting-edge biotechnological solutions and commitment to advancing scientific research, prides itself on delivering high-quality, customizable cell lines to meet the diverse needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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