Gene: PPFIBP1
Official Full Name: PPFIA binding protein 1provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34131 | PPFIBP1 Knockout cell line (HeLa) | Human | PPFIBP1 | 1:3~1:6 | Negative | Online Inquiry |
KO34132 | PPFIBP1 Knockout cell line (HCT 116) | Human | PPFIBP1 | 1:2~1:4 | Negative | Online Inquiry |
KO34133 | PPFIBP1 Knockout cell line (HEK293) | Human | PPFIBP1 | 1:3~1:6 | Negative | Online Inquiry |
KO34134 | PPFIBP1 Knockout cell line (A549) | Human | PPFIBP1 | 1:3~1:4 | Negative | Online Inquiry |
PPFIBP1 Gene Knockout Cell Lines are genetically modified cell lines designed to specifically disrupt the function of the PPFIBP1 gene, which plays critical roles in cellular processes such as cellular adhesion, migration, and signal transduction. By employing CRISPR/Cas9 gene-editing technology, these knockout cell lines allow researchers to investigate the physiological and pathological roles of PPFIBP1 at a fundamental level, providing a powerful tool for understanding gene function in various biological contexts.
The primary function of PPFIBP1 involves its interaction with various signaling pathways and cytoskeletal components, influencing cell morphology and behavior. Researchers utilizing these knockout cell lines can elucidate the consequences of PPFIBP1 deficiency on cellular dynamics, including proliferation, differentiation, and response to external stimuli. This mechanistic understanding is essential for the development of targeted therapies, as aberrations in PPFIBP1 have been correlated with various diseases, including cancer and fibrotic disorders.
The scientific significance of PPFIBP1 Gene Knockout Cell Lines extends across multiple fields of research, including cancer biology, stem cell research, and tissue engineering. In clinical settings, insights gleaned from studies using these cell lines can inform therapeutic strategies aimed at modulating cellular functions disrupted in diseases, thus bridging the gap between fundamental research and clinical application.
Compared to alternative methods such as RNA interference, which may not provide complete gene silencing, PPFIBP1 gene knockout offers a more definitive and stable genetic alteration. This specificity allows for more accurate modeling of disease and biological processes, making these cell lines preferable for rigorous scientific investigations.
Researchers and clinicians will find immense value in the PPFIBP1 Gene Knockout Cell Lines as they facilitate novel insights into gene function and cellular mechanics, ultimately contributing to advancements in therapeutic approaches. Our company, with its dedication to high-quality biological products, brings extensive expertise in genetic modification technologies, ensuring that our offerings meet the rigorous demands of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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