Gene: PPFIA3
Official Full Name: PTPRF interacting protein alpha 3provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. Liprin family protein has been shown to localize phosphatase LAR to cell focal adhesions and may be involved in the molecular organization of presynaptic active zones. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34073 | PPFIA3 Knockout cell line (HeLa) | Human | PPFIA3 | 1:3~1:6 | Negative | Online Inquiry |
KO34074 | PPFIA3 Knockout cell line (HCT 116) | Human | PPFIA3 | 1:2~1:4 | Negative | Online Inquiry |
KO34075 | PPFIA3 Knockout cell line (HEK293) | Human | PPFIA3 | 1:3~1:6 | Negative | Online Inquiry |
KO34076 | PPFIA3 Knockout cell line (A549) | Human | PPFIA3 | 1:3~1:4 | Negative | Online Inquiry |
PPFIA3 Gene Knockout Cell Lines are specifically engineered cellular models lacking the PPFIA3 (Protein Phosphatase 1, Regulatory Subunit 9) gene, crucial for understanding various biological processes, including cell signaling and cytoskeletal organization. By utilizing CRISPR/Cas9 technology, these cell lines are designed to facilitate detailed investigations of PPFIA3's role in cellular functions, and its implications in diseases such as cancer and neurodevelopmental disorders.
Functionally, the PPFIA3 gene encodes a protein that interacts with other signaling molecules, directly influencing cellular adhesion, migration, and proliferation. The knockout of this gene helps researchers elucidate its specific contributions to these processes, revealing potential pathways for therapeutic intervention. The absence of PPFIA3 alters various signaling cascades, enabling scientists to explore the gene's role in tumorigenesis and its potential as a target for cancer therapies.
The scientific importance of PPFIA3 Gene Knockout Cell Lines spans diverse applications, extending from basic research in cellular mechanisms to applied clinical investigations. These models are invaluable for studying gene function, drug responses, and innovating targeted therapies. The specific knockout of PPFIA3 presents a unique opportunity to dissect its role in cellular biology, enhancing our understanding of many pathological conditions.
Compared to alternative cell lines, our PPFIA3 Gene Knockout Cell Lines offer superior specificity and reliability, with validated gene disruptions confirmed through sequencing and functional assays. These lines enable consistent results and enhance experimental reproducibility, making them an ideal choice for pioneering research.
Researchers and clinicians selecting our PPFIA3 Gene Knockout Cell Lines will find unparalleled utility in their studies. With an ever-expanding focus on personalized medicine and the genomic basis of disease, this product empowers users to advance their research and ultimately contribute to transformative therapies.
Our company stands at the forefront of biotechnology, committed to delivering innovative and reliable biological products that cater to the evolving needs of the research community. Our expertise in genetic engineering ensures that we provide high-quality models that propel scientific discovery forward.
Please note that all services are for research use only. Not intended for any clinical use.
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