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PPEF1 Knockout Cell Lines

Gene: PPEF1

Official Full Name: protein phosphatase with EF-hand domain 1provided by HGNC

Gene Summary: This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35962 PPEF1 Knockout cell line (A549) Human PPEF1 1:3~1:4 Negative Online Inquiry

Background

PPEF1 Gene Knockout Cell Lines are genetically engineered cell lines in which the protein phosphatase with EF-hand calcium-binding domain 1 (PPEF1) gene has been selectively disabled or "knocked out." This product serves as a crucial tool in research, facilitating the study of PPEF1's role in cellular processes such as signal transduction, calcium homeostasis, and various physiological responses. By creating a complete loss of function for the PPEF1 gene, researchers can investigate the associated phenotypic changes, which can provide insights into the gene's involvement in diseases or cellular dysfunction.

The key mechanism underlying these knockout cell lines relies on advanced genome editing techniques, such as CRISPR-Cas9 or homologous recombination, ensuring high specificity and efficiency in gene disruption. Researchers can use these cell lines to evaluate the downstream effects of PPEF1 gene deletion on cellular pathways, which is essential for understanding the molecular mechanisms underlying numerous biological processes.

In clinical settings and pharmaceutical research, PPEF1 Gene Knockout Cell Lines have significant scientific importance. They facilitate drug discovery and testing by providing a model for understanding how targeting PPEF1 could influence disease mechanisms. For example, alterations in calcium signaling pathways have been implicated in various diseases, including cancer and neurodegenerative disorders.

The distinctive advantage of our PPEF1 Gene Knockout Cell Lines lies in their high fidelity and reproducibility, ensuring that researchers obtain consistent and reliable data. Compared to alternative models, these cell lines offer tailored solutions for specific research questions regarding PPEF1's functionalities, helping scientists to make more informed decisions in their studies.

Given the critical role of the PPEF1 gene in cellular signaling and homeostasis, our knockout cell lines are indispensable to researchers and clinicians seeking to unravel complex biological processes and develop targeted therapies. Expertise in genetic engineering and a commitment to high-quality product development underpin our offerings, enabling us to provide researchers with cutting-edge tools to advance their work in cellular biology and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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