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PPCS Knockout Cell Lines

Gene: PPCS

Official Full Name: phosphopantothenoylcysteine synthetaseprovided by HGNC

Gene Summary: Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14954 PPCS Knockout cell line (HeLa) Human PPCS 1:3~1:6 Negative Online Inquiry
KO14955 PPCS Knockout cell line (HCT 116) Human PPCS 1:2~1:4 Negative Online Inquiry
KO14956 PPCS Knockout cell line (HEK293) Human PPCS 1:3~1:6 Negative Online Inquiry
KO14957 PPCS Knockout cell line (A549) Human PPCS 1:3~1:4 Negative Online Inquiry

Background

PPCS Gene Knockout Cell Lines are genetically engineered cell lines in which the PPCS gene (phosphoethanolamine cytidylyltransferase) has been deliberately inactivated or disrupted. These knockout models are invaluable for studying the role of the PPCS gene in cellular metabolism, signal transduction, and various disease states, as they allow researchers to observe the phenotypic consequences of PPCS deficiency in various biological processes.

The primary function of PPCS Gene Knockout Cell Lines is to facilitate the comprehensive investigation of PPCS-related pathways and their implications in disease mechanisms. By eliminating this gene, researchers can explore the impact of its absence on intracellular signaling, lipid metabolism, and the biosynthesis of phospholipids. The knockout cells serve as crucial tools for elucidating complex interactions within metabolic networks and provide a platform for drug discovery and validation of therapeutic targets.

In the realm of scientific research, these cell lines are pivotal for functional genomics and pharmacological studies. As PPCS is implicated in various metabolic disorders, these models are particularly relevant for investigating conditions such as cancer and neurological diseases. Researchers can utilize these cell lines to screen potential compounds that may normalize dysregulated pathways, expediting advancements in therapeutic strategies.

One distinctive advantage of PPCS Gene Knockout Cell Lines is their ready availability, allowing for immediate experimentation without the need for laborious gene editing processes. Compared to other alternative models, these lines are optimized through rigorous standardization, ensuring reproducibility and reliability in results. This means that researchers can trust the data generated from these lines, facilitating alignment with regulatory requirements.

The value of PPCS Gene Knockout Cell Lines extends beyond mere experimentation; they offer insights into fundamental biological questions and hold promise for translating findings into clinical applications that can benefit patients. By incorporating these models into research, scientists can drive innovation and accelerate the development of targeted therapies.

Our company prides itself on a robust commitment to providing high-quality biological products for research and clinical applications. With extensive expertise in cellular and molecular biology, we ensure that our products meet the highest standards, empowering researchers and clinicians to achieve transformative results in their investigations.

Please note that all services are for research use only. Not intended for any clinical use.

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