Gene: POU2AF3
Official Full Name: POU class 2 homeobox associating factor 3provided by HGNC
Gene Summary: Enables DNA binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14962 | POU2AF3 Knockout cell line (HEK293) | Human | POU2AF3 | 1:3~1:6 | Negative | Online Inquiry |
POU2AF3 Gene Knockout Cell Lines represent a cutting-edge tool for researchers investigating the functional roles of the POU2AF3 gene, which encodes a transcription factor crucial for B-cell and T-cell development and immune response regulation. These specialized cell lines have been engineered through site-specific genome editing techniques, such as CRISPR-Cas9, to create a precise knockout of the POU2AF3 gene, allowing for the in-depth study of its biological functions and the cellular pathways it influences.
The key function of these knockout cell lines lies in their ability to model the absence of POU2AF3, offering insights into cellular mechanisms involved in immune response and oncogenesis. By ablating this gene, researchers are able to assess alterations in gene expression, protein interactions, and metabolic processes that are typically regulated by POU2AF3. This can lead to a better understanding of diseases such as lymphomas and other immune-related disorders, making it invaluable in both academic research and clinical settings.
Unlike traditional cell lines where POU2AF3 expression is not altered, these knockout models present an innovative advantage. Their specificity allows for clearer delineation of gene function and the consequent impacts of gene knockout on cell behavior, which can be obscured in wild-type cell lines. Moreover, they facilitate the screening of potential therapeutics aimed at modulating POU2AF3-related pathways, thus bridging basic research with translational and clinical applications.
Research institutions and biotechnology firms alike will find immense value in POU2AF3 Gene Knockout Cell Lines, as they not only streamline experimental design but also offer reliable, reproducible data that can lead to novel discoveries in immunology and cancer biology. Our company, with its strong expertise in gene editing technologies and commitment to advancing biological research, is proud to offer these knockout cell lines, reinforcing our position at the forefront of innovative biological product development.
Please note that all services are for research use only. Not intended for any clinical use.
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