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POGLUT2 Knockout Cell Lines

Gene: POGLUT2

Official Full Name: protein O-glucosyltransferase 2provided by HGNC

Gene Summary: This gene encodes a protein product localized to the lumen of the endoplasmic reticulum. As a member of the endoplasmic reticulum protein family the encoded protein contains a Lys-Asp-Glu-Leu or KDEL motif located at the extreme C-terminus which prevents all endoplasmic reticulum resident proteins from being secreted. Proteins carrying this motif are bound by a receptor in the Golgi apparatus so that the receptor-ligand complex returns to the endoplasmic reticulum. A processed non-transcribed pseudogene located in an intron of a sodium transporter gene on chromosome 5 has been defined for this gene. This gene has multiple transcript variants which are predicted to encode distinct isoforms. [provided by RefSeq, Jan 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14984 POGLUT2 Knockout cell line (HeLa) Human POGLUT2 1:3~1:6 Negative Online Inquiry
KO14985 POGLUT2 Knockout cell line (HCT 116) Human POGLUT2 1:2~1:4 Negative Online Inquiry
KO14986 POGLUT2 Knockout cell line (HEK293) Human POGLUT2 1:3~1:6 Negative Online Inquiry
KO14987 POGLUT2 Knockout cell line (A549) Human POGLUT2 1:3~1:4 Negative Online Inquiry

Background

POGLUT2 Gene Knockout Cell Lines are genetically engineered cell lines designed specifically for the study of the POGLUT2 gene, which encodes a protein involved in O-linked glycosylation processes. This product enables researchers to dissect the functional roles of POGLUT2 in various biological processes and disease states, by providing a reliable model where the gene is inactivated. The key mechanism by which these knockout cell lines operate is through the complete or partial ablation of POGLUT2 expression, allowing for the investigation of downstream signaling pathways and biological responses in a controlled environment.

The scientific importance of POGLUT2 Gene Knockout Cell Lines lies in their potential applications across various research domains, including cancer biology, developmental biology, and neuroscience. By elucidating the role of POGLUT2 in these systems, researchers can gain insights into its involvement in cell signaling, differentiation, and pathology. Additionally, these knockout models are invaluable for validating therapeutic targets in drug discovery and for understanding the consequences of POGLUT2 dysregulation.

Compared to traditional methods of gene silencing, such as RNA interference, POGLUT2 Gene Knockout Cell Lines offer a more permanent and stable solution for studying gene function. They circumvent the potential variability associated with transient knockdown strategies and provide higher fidelity in replicating loss-of-function phenotypes. As a result, researchers can achieve consistent and reproducible results that enhance the reliability of their findings.

For researchers, clinicians, and biotechnology companies, the value of POGLUT2 Gene Knockout Cell Lines cannot be overstated. They facilitate a deeper understanding of gene function, pave the way for innovative therapeutic strategies, and ultimately contribute to advancements in personalized medicine. Our company specializes in developing cutting-edge biological products, backed by extensive research and a commitment to quality, ensuring you have access to reliable tools that propel your scientific discoveries forward.

Please note that all services are for research use only. Not intended for any clinical use.

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