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POF1B Knockout Cell Lines

Gene: POF1B

Official Full Name: POF1B actin binding proteinprovided by HGNC

Gene Summary: Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called "POF1" and "POF2" have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined. [provided by RefSeq, Jan 2010]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14992 POF1B Knockout cell line (A549) Human POF1B 1:3~1:4 Negative Online Inquiry

Background

POF1B Gene Knockout Cell Lines are specialized eukaryotic cell lines that have undergone precise genetic modification to disrupt the expression of the POF1B gene, known for its role in cellular processes and development. These cell lines serve as a crucial tool for researchers studying gene function, cellular signaling pathways, and the molecular basis of diseases that may be influenced by POF1B activity.

The primary function of the POF1B Gene Knockout Cell Lines rests in their ability to facilitate the investigation of gene loss effects on cellular behavior. The knockout mechanism is achieved through techniques such as CRISPR-Cas9, ensuring that the POF1B gene is effectively inactivated. By examining phenotypic changes, gene interaction networks, and compensatory mechanisms, researchers can elucidate the biological roles of POF1B and how its dysregulation might contribute to pathological conditions.

In scientific research and clinical applications, these knockout cell lines hold immense significance. They can be utilized in drug development to screen for potential therapeutic agents, in the study of genetic diseases where POF1B is implicated, and in fundamental research aimed at understanding cellular differentiation and development. The ability to model diseases in vitro accelerates the pace of discovery and enhances translational research efforts.

What sets our POF1B Gene Knockout Cell Lines apart from alternatives is their high specificity and quality control. Each line is validated for consistent genetic knockout efficiency, ensuring reliability in experimental outcomes. Furthermore, these cell lines are designed for ease of use, with optimized growth conditions that simplify the experimental workflow.

For researchers and clinicians striving for reliable and reproducible results in their studies, our POF1B Gene Knockout Cell Lines represent an invaluable resource. They not only provide insights into gene function and disease mechanisms but also help bridge the gap between basic and applied biomedical research.

With extensive expertise in the field of genetic engineering and a commitment to advancing life science research, our company is dedicated to offering high-quality biological products, including the POF1B Gene Knockout Cell Lines, to empower scientific progress across diverse disciplines.

Please note that all services are for research use only. Not intended for any clinical use.

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