Gene: PNPLA6
Official Full Name: patatin like domain 6, lysophospholipaseprovided by HGNC
Gene Summary: This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01907 | PNPLA6 Knockout cell line (HeLa) | Human | PNPLA6 | 1:3~1:6 | Negative | Online Inquiry |
KO01908 | PNPLA6 Knockout cell line (HCT 116) | Human | PNPLA6 | 1:2~1:4 | Negative | Online Inquiry |
KO01909 | PNPLA6 Knockout cell line (HEK293) | Human | PNPLA6 | 1:3~1:6 | Negative | Online Inquiry |
KO01910 | PNPLA6 Knockout cell line (A549) | Human | PNPLA6 | 1:3~1:4 | Negative | Online Inquiry |
PNPLA6 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the expression of the PNPLA6 gene, a critical component associated with various cellular processes such as lipid metabolism and neuronal function. By functioning as an essential regulator within the endocannabinoid signaling pathway, PNPLA6 plays pivotal roles in modulating cellular responses to multiple physiological stimuli. The knockout of this gene allows researchers to investigate the gene's specific contributions to metabolic disorders, neurological diseases, and other pathophysiological conditions, providing invaluable insights into its mechanisms.
These cell lines operate through the absence of PNPLA6, enabling the exploration of downstream effects on signaling pathways and cellular processes normally influenced by this protein. The knockouts facilitate the study of metabolic dysregulation and potential therapeutic targets for conditions related to lipid accumulation and neurodegenerative diseases, making them highly relevant in both research and clinical settings.
The scientific significance of PNPLA6 Gene Knockout Cell Lines lies in their ability to serve as a model system for elucidating the underlying biological processes associated with PNPLA6 dysfunction. Compared to other models, such as overexpression systems or wild-type cell lines, these knockout lines offer a clearer and more controlled environment to study the loss-of-function effects specific to this gene.
For researchers and clinicians alike, these cell lines represent a unique opportunity to advance knowledge in fields ranging from metabolic engineering to therapeutic drug development. Their value lies in providing an efficient platform for validating hypotheses, assessing drug efficacy, and uncovering novel pathways related to critical cellular functions.
Our company specializes in the development of cutting-edge genetic models and cell lines that facilitate groundbreaking research, equipping scientists with the tools necessary to drive advancements in understanding human health and disease. By leveraging our expertise, you can enhance your research capabilities with our high-quality PNPLA6 Gene Knockout Cell Lines.
Please note that all services are for research use only. Not intended for any clinical use.
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