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PNLDC1 Knockout Cell Lines

Gene: PNLDC1

Official Full Name: PARN like ribonuclease domain containing exonuclease 1provided by HGNC

Gene Summary: Enables poly(A)-specific ribonuclease activity. Involved in nuclear-transcribed mRNA poly(A) tail shortening; piRNA processing; and spermatogenesis. Located in endoplasmic reticulum. Implicated in spermatogenic failure 57. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00492 PNLDC1 gRNA1-gRNA2 KO plasmid PNLDC1 $850
KO00784 PNLDC1 Knockout cell line(HCT 116) Human PNLDC1 1:2~1:4 Negative Online Inquiry

Background

PNLDC1 Gene Knockout Cell Lines are specifically engineered cell lines that exhibit targeted deletion of the PNLDC1 gene, which plays a critical role in the regulation of RNA processing and metabolism. These cell lines have been created using advanced CRISPR/Cas9 technology, allowing researchers to study the functional implications of PNLDC1 disruption in various biological contexts. By elucidating changes in cellular pathways associated with PNLDC1 knockout, scientists gain valuable insights into its role in cellular differentiation, proliferation, and response to stress.

The key mechanism by which these knockout cell lines operate is through the silencing of the PNLDC1 gene, effectively allowing researchers to observe the phenotypic and molecular consequences of its absence. Utilizing these cell lines enables a more profound understanding of PNLDC1's involvement in biological processes such as RNA degradation, alternative splicing, and immune response modulation, making them indispensable tools for basic and applied research.

In both research and clinical settings, PNLDC1 Gene Knockout Cell Lines serve as a beneficial model for investigating diseases linked to RNA dysregulation, including autoimmune disorders and cancers. Their versatility allows for applications ranging from drug screening to the development of gene therapy strategies, providing a robust platform for advancing scientific knowledge and therapeutic interventions.

What sets PNLDC1 Gene Knockout Cell Lines apart from other models is their precision and reliability, significantly reducing experimental variability and enhancing reproducibility in studies. These cell lines are subjected to rigorous validation processes to ensure the specificity of the knockout, providing researchers with a high level of confidence in their findings.

For researchers and clinicians aiming to explore the intricate role of RNA biology in health and disease, PNLDC1 Gene Knockout Cell Lines offer an invaluable resource, enabling comprehensive investigations into gene function that could lead to innovative treatment strategies. Our company prides itself on delivering high-quality, meticulously validated biological products, backed by a team of experts committed to advancing the frontiers of biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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