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PLPPR3 Knockout Cell Lines

Gene: PLPPR3

Official Full Name: phospholipid phosphatase related 3provided by HGNC

Gene Summary: The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20229 PLPPR3 Knockout cell line (HEK293) Human PLPPR3 1:3~1:6 Negative Online Inquiry
KO20230 PLPPR3 Knockout cell line (A549) Human PLPPR3 1:3~1:4 Negative Online Inquiry

Background

PLPPR3 Gene Knockout Cell Lines are specialized cellular models developed through the targeted disruption of the PLPPR3 gene, which encodes a protein implicated in various cellular processes, including cell signaling and membrane dynamics. These knockout cell lines provide researchers with a powerful tool for studying gene function, elucidating signaling pathways, and exploring the biological implications of PLPPR3 deficiency.

The key function of PLPPR3 Gene Knockout Cell Lines lies in their ability to mimic the loss-of-function phenotype associated with the targeted gene. By utilizing CRISPR/Cas9 technology or other genomic editing methods, these cell lines enable precise investigations into the biological roles of PLPPR3, allowing for detailed mechanistic studies in a controlled environment. Researchers can observe changes in cellular behavior, receptor signaling, and metabolic pathways, enabling them to gain insights into the gene's contributions to health and disease.

In scientific research and clinical settings, the importance of these knockout cell lines is significant. They facilitate the exploration of diseases where PLPPR3 is implicated, such as neurodegenerative disorders and cancer. Moreover, these models are invaluable for drug discovery and the assessment of therapeutic targets, providing a platform to test potential interventions in a relevant cellular context.

One of the distinguishing advantages of our PLPPR3 Gene Knockout Cell Lines is the high specificity and efficiency of the gene editing process, ensuring reliable and reproducible results. Compared to alternative models, such as transient knockdown systems, our knockout lines provide a stable and consistent background for long-term experiments, significantly enhancing the reliability of biological data.

For researchers and clinicians seeking to deepen their understanding of cellular mechanisms and develop therapeutic strategies against diseases associated with PLPPR3 dysfunction, these cell lines are an indispensable resource. With decades of experience in creating high-quality biological products, our company stands at the forefront of genomic innovation, committed to advancing research through precision tools and reliable technologies.

Please note that all services are for research use only. Not intended for any clinical use.

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