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PLP2 Knockout Cell Lines

Gene: PLP2

Official Full Name: proteolipid protein 2provided by HGNC

Gene Summary: This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked cognitive disability. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03774 PLP2 Knockout cell line (HeLa) Human PLP2 1:3~1:6 Negative Online Inquiry
KO03775 PLP2 Knockout cell line (HCT 116) Human PLP2 1:2~1:4 Negative Online Inquiry
KO03776 PLP2 Knockout cell line (HEK293) Human PLP2 1:3~1:6 Negative Online Inquiry
KO03777 PLP2 Knockout cell line (A549) Human PLP2 1:3~1:4 Negative Online Inquiry

Background

PLP2 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to disrupt the expression of the PLP2 gene, a critical component implicated in various biological processes. These cell lines provide researchers with an invaluable tool for studying the functional role of PLP2 within the context of cellular activities, signaling pathways, and disease mechanisms. By utilizing CRISPR-Cas9 technology for precise genome editing, these knockout lines ensure reliable gene disruption, allowing for the examination of PLP2's contributions to physiological and pathological conditions.

The primary function of the PLP2 Gene Knockout Cell Lines lies in their ability to facilitate targeted investigations of PLP2's role in cellular behavior and development. The knockout of this gene often leads to notable phenotypic changes, which can be assessed through various assays to elucidate its involvement in neurological disorders, myelination processes, and related pathways. By studying these alterations, researchers can gain insights into potential therapeutic targets and biomarkers for diseases where PLP2 is implicated.

The scientific importance of these cell lines extends to both fundamental research and clinical applications. In preclinical settings, they serve as platforms for drug discovery, allowing for the testing of therapeutics aimed at modulating PLP2-related pathways. Moreover, they can be utilized to dissect the molecular mechanics of gene-related diseases, thereby contributing to the understanding of gene-environment interactions in pathophysiology.

What sets PLP2 Gene Knockout Cell Lines apart from alternative models is their specificity and reliability in gene editing, coupled with extensive validation to ensure consistent performance in experiments. Unlike traditional methods that may generate ambiguous results, these knockout cell lines present a straightforward approach to functional analysis, significantly reducing the complexity in experimental designs.

For researchers and clinicians aiming to unravel the complexities of gene function and disease mechanisms, PLP2 Gene Knockout Cell Lines serve as a vital resource. Their potential to drive innovation in research and therapeutic development makes them indispensable in the rapidly advancing field of molecular biology and genetics. With years of expertise in gene editing technologies, our company is dedicated to providing researchers with high-quality, validated biological products designed to meet their evolving research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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