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PLLP Knockout Cell Lines

Gene: PLLP

Official Full Name: plasmolipinprovided by HGNC

Gene Summary: Enables identical protein binding activity. Involved in myelin assembly and regulation of transcytosis. Located in myelin sheath and plasma membrane. Biomarker of schizophrenia. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23079 PLLP Knockout cell line (HeLa) Human PLLP 1:3~1:6 Negative Online Inquiry
KO23080 PLLP Knockout cell line (HCT 116) Human PLLP 1:2~1:4 Negative Online Inquiry
KO23081 PLLP Knockout cell line (HEK293) Human PLLP 1:3~1:6 Negative Online Inquiry
KO23082 PLLP Knockout cell line (A549) Human PLLP 1:3~1:4 Negative Online Inquiry

Background

PLLP Gene Knockout Cell Lines are a powerful research tool designed for investigating the physiological roles and molecular mechanisms of the PLLP gene in a variety of cellular contexts. These cell lines are genetically modified to lack the expression of the phospholipid transfer protein (PLLP), facilitating the study of its involvement in lipid metabolism, cell signaling, and various disease states, particularly in neurodegenerative conditions where lipid dysregulation plays a critical role.

The primary function of these cell lines lies in their ability to serve as a robust platform for gene function studies. By eliminating PLLP expression, researchers can monitor the downstream effects on cell signaling pathways and metabolic processes, providing invaluable insights into the gene’s role. Mechanistically, the loss of PLLP can alter phospholipid homeostasis and membrane integrity, enabling the assessment of these changes on cellular behavior, including proliferation, differentiation, and apoptosis.

The scientific importance of PLLP Gene Knockout Cell Lines extends to both basic research and clinical applications. In research, they facilitate the dissection of complex biological pathways and contribute to the understanding of lipid-related diseases, making them essential in drug discovery and testing. In clinical settings, insights gleaned from these cell lines could inform therapeutic strategies targeting lipid metabolism disorders.

Compared to traditional gene silencing methods like RNA interference, gene knockout cell lines offer a more stable and permanent solution for studying gene function, which can yield reproducible results over extended periods. Additionally, these cell lines provide a clear baseline for comparison with wild-type cells, enhancing the reliability of experimental data.

For researchers and clinicians, PLLP Gene Knockout Cell Lines represent a unique opportunity to explore the foundational aspects of lipid biology and its implications in health and disease. The ability to manipulate and study the effects of specific gene loss significantly enriches the understanding of numerous biological processes.

Our company stands at the forefront of developing innovative tools for genetic modification and cell line generation, ensuring that your research is supported by high-quality, reliable products that are backed by extensive scientific expertise. With our PLLP Gene Knockout Cell Lines, you will have the resources needed to uncover the complexities of lipid biology and drive your research forward.

Please note that all services are for research use only. Not intended for any clinical use.

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