Gene: PLEKHG5
Official Full Name: pleckstrin homology and RhoGEF domain containing G5provided by HGNC
Gene Summary: This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15051 | PLEKHG5 Knockout cell line (HeLa) | Human | PLEKHG5 | 1:3~1:6 | Negative | Online Inquiry |
KO15052 | PLEKHG5 Knockout cell line (HCT 116) | Human | PLEKHG5 | 1:2~1:4 | Negative | Online Inquiry |
KO15053 | PLEKHG5 Knockout cell line (HEK293) | Human | PLEKHG5 | 1:3~1:6 | Negative | Online Inquiry |
KO15054 | PLEKHG5 Knockout cell line (A549) | Human | PLEKHG5 | 1:3~1:4 | Negative | Online Inquiry |
PLEKHG5 Gene Knockout Cell Lines are genetically engineered cells where the PLEKHG5 gene has been purposely disrupted to investigate its role in cellular functions and related biological processes. This innovation allows researchers to observe the phenotypic consequences of the absence of PLEKHG5, a gene known to play a crucial role in cytoskeletal organization and signal transduction pathways.
The primary mechanism of action involves the targeted disruption of PLEKHG5, leading to alterations in cellular mechanisms such as growth, differentiation, and response to external stimuli. This knockout model is invaluable for studying the contributions of PLEKHG5 to diseases, particularly those related to neurological disorders and cancer, as its dysregulation has been implicated in various pathophysiological conditions.
From a scientific standpoint, PLEKHG5 Gene Knockout Cell Lines facilitate advanced research into the gene’s functional impact and its interactions with other cellular pathways. Researchers can utilize these cell lines in drug discovery processes, functional genomics, and investigations into therapeutic interventions, making them a critical tool in both academic and clinical research settings.
What sets our PLEKHG5 Gene Knockout Cell Lines apart from alternatives is our commitment to precision gene editing, resulting in highly reproducible and validated models. Compared to conventional knockout methods, our innovative approach ensures minimal off-target effects and a more robust phenotype characterization.
The value of our product lies in its ability to empower researchers and clinicians with the tools necessary to unravel complex biological mechanisms and potentially discover novel therapeutic targets. By understanding the specific roles of PLEKHG5, users can advance their research towards impactful scientific discoveries.
With a strong background in genetic engineering and cell biology, our company is dedicated to providing high-quality biological products that meet the evolving demands of the research community. Our expertise guarantees not only the reliability of our PLEKHG5 Gene Knockout Cell Lines but also a commitment to supporting groundbreaking research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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