Gene: PLEKHG4
Official Full Name: pleckstrin homology and RhoGEF domain containing G4provided by HGNC
Gene Summary: The protein encoded by this gene can function as a guanine nucleotide exchange factor (GEF) and may play a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Polymorphisms in the region of this gene have been found to be associated with spinocerebellar ataxia in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28671 | PLEKHG4 Knockout cell line (HeLa) | Human | PLEKHG4 | 1:3~1:6 | Negative | Online Inquiry |
KO28672 | PLEKHG4 Knockout cell line (HCT 116) | Human | PLEKHG4 | 1:2~1:4 | Negative | Online Inquiry |
KO28673 | PLEKHG4 Knockout cell line (HEK293) | Human | PLEKHG4 | 1:3~1:6 | Negative | Online Inquiry |
KO28674 | PLEKHG4 Knockout cell line (A549) | Human | PLEKHG4 | 1:3~1:4 | Negative | Online Inquiry |
PLEKHG4 Gene Knockout Cell Lines are a cutting-edge biological product designed for advanced genetic research and therapeutic applications. These cell lines are engineered to exhibit a complete knockout of the PLEKHG4 gene, which encodes for a guanine nucleotide exchange factor involved in various cellular processes, including cytoskeletal dynamics and extracellular signal transduction. By eliminating the function of this gene, researchers are provided with a unique tool to study the downstream effects on cellular behavior and signaling pathways.
The primary mechanism of action in PLEKHG4 knockout cell lines involves the disruption of normal signaling cascades that govern cell proliferation, differentiation, and apoptosis. This allows for an in-depth exploration of the role that PLEKHG4 plays in both normal physiology and in the context of disease states, such as cancer and metabolic disorders. The ability to observe phenotypic changes in response to the lack of PLEKHG4 activity makes these cell lines invaluable for elucidating novel biological mechanisms.
From a scientific perspective, these knockout cell lines hold significant importance in both academic research and clinical studies. They offer researchers the capability to create model systems that mimic specific disease characteristics, facilitating drug development and potential therapeutic interventions. Moreover, PLEKHG4 knockout models help in the identification of potential biomarkers and therapeutic targets, making them an essential resource in translational medicine.
Compared to conventional cell lines, the PLEKHG4 knockout cells provide distinct advantages, including a higher specificity in targeting the PLEKHG4 gene with assured consistency across experiments. Their design underscores a commitment to reliability and reproducibility, characteristics that are critical in scientific inquiry.
For researchers and clinicians invested in understanding cellular mechanisms or developing targeted therapies, PLEKHG4 Gene Knockout Cell Lines represent a pivotal asset. They not only enhance the depth of genetic studies but also pave the way for innovative solutions in precision medicine.
With a firm foundation in biotechnology and comprehensive expertise, our company is dedicated to delivering high-quality biological products that empower the scientific community and drive cutting-edge research forward.
Please note that all services are for research use only. Not intended for any clinical use.
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