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PLEKHG3 Knockout Cell Lines

Gene: PLEKHG3

Official Full Name: pleckstrin homology and RhoGEF domain containing G3provided by HGNC

Gene Summary: Enables actin binding activity. Involved in regulation of cell migration and regulation of establishment of cell polarity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28460 PLEKHG3 Knockout cell line (HeLa) Human PLEKHG3 1:3~1:6 Negative Online Inquiry
KO28461 PLEKHG3 Knockout cell line (HCT 116) Human PLEKHG3 1:2~1:4 Negative Online Inquiry
KO28462 PLEKHG3 Knockout cell line (HEK293) Human PLEKHG3 1:3~1:6 Negative Online Inquiry
KO28463 PLEKHG3 Knockout cell line (A549) Human PLEKHG3 1:3~1:4 Negative Online Inquiry

Background

PLEKHG3 Gene Knockout Cell Lines are specifically engineered cellular models that facilitate the study of the PLEKHG3 gene, known for its role in cell signaling and cytoskeletal organization. These knockout cell lines are generated using advanced CRISPR-Cas9 gene editing technology, rendering the PLEKHG3 gene nonfunctional. This allows researchers to investigate the gene's contributions to various biological processes, such as cell migration, adhesion, and proliferation.

The primary function of the PLEKHG3 knockout is to provide insights into the molecular pathways influenced by this gene, particularly in the context of cancer biology and other diseases where cytoskeletal dynamics are dysregulated. By assessing cellular behaviors and responses in the absence of functional PLEKHG3, scientists can better understand its role in disease mechanisms, leading to potential therapeutic targets.

The scientific importance of these knockout cell lines lies in their versatility for both basic and translational research. They are crucial in drug discovery and development, enabling the identification of novel compounds that can modulate related pathways. Moreover, these models can be utilized in gene therapy research, enhancing the understanding of gene function and regulation.

Compared to alternative models, PLEKHG3 Gene Knockout Cell Lines offer the unique advantage of significant specificity, resulting from targeted gene deletion. This specificity ensures more accurate experimental results, minimizing off-target effects that can confound data interpretation. Additionally, the robustness of these cell lines allows for reproducibility across multiple experiments, making them reliable tools for researchers.

For researchers and clinicians invested in the fields of cell biology, oncology, and genetic research, the PLEKHG3 gene knockout cell lines represent valuable resources. They provide a reliable platform for exploring complex biological questions, generating hypotheses, and validating therapeutic approaches.

Our company specializes in providing top-tier biotechnological solutions, employing state-of-the-art gene editing techniques to deliver high-quality products for research and clinical applications. With a commitment to scientific excellence, we empower the research community with tools that advance knowledge and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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