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PLCL2 Knockout Cell Lines

Gene: PLCL2

Official Full Name: phospholipase C like 2provided by HGNC

Gene Summary: Enables GABA receptor binding activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway; negative regulation of cold-induced thermogenesis; and regulation of GABAergic synaptic transmission. Predicted to act upstream of or within B cell proliferation involved in immune response; B-1a B cell differentiation; and negative regulation of B cell receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29671 PLCL2 Knockout cell line (HeLa) Human PLCL2 1:3~1:6 Negative Online Inquiry
KO29672 PLCL2 Knockout cell line (HCT 116) Human PLCL2 1:2~1:4 Negative Online Inquiry
KO29673 PLCL2 Knockout cell line (HEK293) Human PLCL2 1:3~1:6 Negative Online Inquiry
KO29674 PLCL2 Knockout cell line (A549) Human PLCL2 1:3~1:4 Negative Online Inquiry

Background

PLCL2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to disable the PLCL2 gene, which encodes a phospholipase involved in various signaling pathways critical for cellular function, growth, and development. By utilizing CRISPR/Cas9 gene-editing technology, these knockout cell lines allow researchers to investigate the role of PLCL2 in cellular signaling, immune response, and disease pathology.

The fundamental mechanism behind these cell lines lies in the targeted disruption of the PLCL2 gene, leading to a loss of functional protein. This results in a cascade of downstream effects that can be analyzed to better understand the gene's physiological significance. Researchers can observe alterations in calcium signaling, lipid metabolism, and apoptotic pathways, making these cell lines a vital tool for unravelling complex biological processes and disease mechanisms.

The scientific importance of PLCL2 Gene Knockout Cell Lines extends into both research and clinical settings. They can be utilized to model diseases characterized by dysregulated signaling pathways, such as cancer and autoimmune disorders, providing valuable insights into potential therapeutic targets. Moreover, such models offer performance advantages when screening for drug candidates that accurately reflect the biological landscape of human pathologies.

What sets our PLCL2 Gene Knockout Cell Lines apart from alternative models is their high specificity, consistent knockout efficiency, and adaptability for various experimental conditions. These features enhance reproducibility and provide reliable data, addressing a common challenge in biological research. Furthermore, our cell lines are thoroughly characterized for consistent performance, allowing researchers to focus on their investigations without worrying about variability.

Investing in PLCL2 Gene Knockout Cell Lines not only accelerates research pursuits but also empowers researchers and clinicians to contribute to key advancements in understanding cellular behavior and developing targeted therapies. With a solid foundation in genetic engineering and extensive expertise in producing cutting-edge biological products, our company is committed to supporting the scientific community with high-quality, reliable tools for transformative research.

Please note that all services are for research use only. Not intended for any clinical use.

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